在患有甲状腺癌和甲状腺功能低下症的患者中长期的非骨性并发症 总体甲状腺切除术后
Eu Jeong Ku1, Jooyoung Lee2, Won Sang Yoo3
1Department of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea.
The Journal of clinical endocrinology and metabolism
|April 2, 2025
概括
患有甲状腺癌的甲状腺功能低下症患者面临糖尿病,脂质不良,尿路结石和白内障的更高风险. 这凸显了在这个脆弱的患者群体中需要有针对性的监测和管理.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 眼科医生 眼科 眼科
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 由于诊断的改善,甲状腺癌 (TC) 的发病率正在上升.
- 在TC患者手术后的小甲状腺功能下降会导致长期的健康问题.
- 这项研究调查了TC患者的非骨性并发症风险.
研究的目的:
- 为了评估甲状腺癌患者的非骨性并发症的风险,甲状腺功能低下症.
- 为了比较TC患者和没有hypoparathyroidism之间的并发症风险,和匹配的对照.
- 为了确定特定的非骨性疾病,与甲状腺功能低下症相关的甲状腺癌后手术.
主要方法:
- 使用国家医疗保险服务-国家样本队列 (2002-2019) 的回顾性队列研究.
- 包括2006年至2019年期间诊断的TC患者,分为TC患有缺甲状腺症 (TC有hypoparathyroidism),TC没有缺甲状腺症 (TC没有hypoparathyroidism) 和匹配的对照.
- 倾向性得分匹配和考克斯比例风险模型被用于评估并发症风险.
主要成果:
- 与对照组相比,TC与低P组显示糖尿病 (HR 1.31),脂质失调 (HR 1.29),尿路结石 (HR 1.61) 和白内障 (HR 1.50) 的风险明显更高.
- 在TC中,高血压风险在TC中与低血压相比,高血压风险在TC中较高 (HR 1.39).
- 女性有较高的尿路结石风险,50岁以上患者的白内障风险增加.
结论:
- 患有甲状腺癌的甲状腺功能低下症患者面临特定非骨并发症的风险增加.
- 老年人和女性特别容易患上这些并发症.
- 针对性的监测和管理策略对于TC患者具有hypoparathyroidism至关重要.
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