胰腺状况不是囊性纤维化相关骨疾病的危险因素
Miri Dotan1,2, Maya Trau2, Meir Mei-Zahav1,2
1Kathy and Lee Graub Cystic Fibrosis Center, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Pediatric pulmonology
|April 2, 2025
概括
囊性纤维化相关的骨病 (CFBD) 影响胰腺充足和不足的人同样. 对于所有患有囊性纤维化的人,无论胰腺状况如何,都建议对CFBD进行查.
科学领域:
- 骨代谢和内分泌学 骨代谢和内分泌学
- 肺部医学 肺部医学
- 遗传学和基因组学 遗传学和基因组学
背景情况:
- 增加患有囊性纤维化 (PwCF) 的人的预期寿命需要了解长期并发症.
- 与CF相关的骨病 (CFBD) 是一个需要进一步描述的重大并发症.
研究的目的:
- 在PwCF中纵向评估CFBD.
- 为了比较胰腺充足 (PS) 和胰腺不足 (PI) 之间的骨健康,PwCF.
主要方法:
- 用2008-2021年双能X射线吸收度 (DXA) 数据对8岁以上的PwCF进行纵向分析.
- 收集有关骨代谢标志物,营养,活动,骨折和人口统计数据的数据.
- 在PS和PI组之间对骨密度和Z分数进行比较.
主要成果:
- 80个PwCF包括32个PS (40%) 和48个PI (60%).
- 在PS和PI组中,类似的DXA结果和低Z分数 (<-2) 的患病率 (分别为50%与54%和9%与15%).
- 胰腺功能不良不是CFBD的风险因素;女性性别是病态Z-score的唯一显著风险因素.
结论:
- CFBD的患病率和严重程度与胰腺功能不足状态没有相关性.
- 骨健康在PS和PI PwCF之间是可比的.
- 对于所有PwCF患者,无论胰腺状况如何,建议对CFBD进行普遍查和治疗.
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