在妊娠糖尿病中第一季度的血液学指数:一个元分析
Faegheh Firouzi1, Fahimeh Ramezani Tehrani2,3, Hojat Shaharki4
1Tehran Medical Branch, Islamic Azad University, Tehran 19395-1495, Iran.
Journal of the Endocrine Society
|April 2, 2025
概括
在孕期糖尿病 (GDM) 发病的女性中,第一季度的血液学指数,如血红蛋白,红细胞和白细胞数量显著更高. 这些血液参数可以作为GDM风险评估的早期指标.
科学领域:
- 产科和妇科 产科和妇科
- 血液学 血液学 血液学
- 内分泌学 在内分泌学.
背景情况:
- 孕期糖尿病 (GDM) 是一个重要的妊娠并发症.
- 怀孕早期血液参数与GDM风险之间的关联越来越感兴趣.
- 血液学指数可以提供关于GDM发展的见解.
研究的目的:
- 进行一项元分析,评估第一季度血液学指数与GDM随后的发展之间的关联.
- 为了评估GDM检测特定血液参数的诊断性能.
主要方法:
- 在多个数据库 (PubMed,科学网等) 中进行全面的文献搜索. ) 的情况.
- 包括使用PECO框架的33项研究,涉及247107名孕妇.
- 统计分析包括标准化平均差异,聚合赔率比率和诊断赔率比率 (DOR).
主要成果:
- 与对照组相比,GDM组的血红蛋白,红细胞 (RBC) 计数,血红素,血小板计数,白细胞 (WBC),淋巴细胞,中性粒细胞和中性粒细胞-淋巴细胞比率显著更高.
- 血红蛋白水平与增加的GDM风险有显著关联 (aOR:1.02).
- 在区分GDM病例时,观察到血红蛋白 (3.21) 和平均血小板体积 (2.94) 的高诊断几率比率 (DOR).
结论:
- 第一个三个月的红血细胞,血小板和白血细胞数量增加与患GDM的可能性更高有关.
- 这些血液学参数显示出作为GDM早期预测标记物的潜力.
- 进一步的研究可以探索这些发现对GDM查的临床有用性.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Pathophysiology of Diabetes
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Diabetes Mellitus: Introduction
Diabetes mellitus consists of chronic metabolic disorders characterized by persistent hyperglycemia. This elevated blood glucose results from defects in insulin secretion, impaired insulin action, or both. Insulin, produced by pancreatic β-cells, is essential for maintaining glucose homeostasis by facilitating cellular glucose uptake for energy or storage. Disruptions in insulin production or function lead to glucose accumulation in the bloodstream, causing the clinical features and long-term...
Type I Diabetes III: Clinical Manifestations
Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
Hyperglycemia
Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...


