肠肺轴:对抗呼吸道病毒感染的"有益力量"
Jianing Zhu1, Zihang Huang1, Ying Lin1
1Clinical Medical College, Yangzhou University, Yangzhou, China.
Frontiers in immunology
|April 2, 2025
概括
肠肺轴显著影响呼吸道病毒感染. 调节肠道微生物群可以增强抗病毒免疫力,并提高对呼吸道病毒的治疗疗效.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 呼吸道病毒感染是一个全球性的健康挑战,治疗选择有限.
- 肠-肺轴描述了肠和肺免疫之间的相互作用,共享先天免疫机制,如模式识别受体 (PRR) 激活.
- 肠道微生物群通过代谢物,免疫细胞贩运和细胞因子调节影响肺部抗病毒反应.
研究的目的:
- 审查肠肺轴在抗病毒免疫对抗呼吸道病毒中的作用.
- 探索调节肠道微生物群的策略,以减轻呼吸道病毒感染.
- 突出需要进一步研究肠肺轴免疫机制,用于新型疗法.
主要方法:
- 关于肠肺轴和呼吸道病毒感染的研究文献综述.
- 分析肠道和肺部之间的免疫系统相互作用.
- 检查肠道微生物群对肺部抗病毒免疫力的影响.
主要成果:
- 肠道功能失调可以加剧呼吸道感染的严重程度,并影响抗病毒治疗的有效性.
- 肠肺轴在抗病毒防御中起着协同作用.
- 器官间的免疫沟通对于控制呼吸道病毒感染至关重要.
结论:
- 肠肺轴是对抗呼吸道病毒的抗病毒免疫的一个关键因素.
- 准肠道微生物群是治疗呼吸道病毒感染的一个有希望的策略.
- 进一步研究肠肺轴对于开发创新的临床治疗方法至关重要.
更多相关视频
07:36Contact-Free Co-Culture Model for the Study of Innate Immune Cell Activation During Respiratory Virus Infection
Published on: February 28, 2021
2.8K
09:02Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions
Published on: September 22, 2023
1.1K
相关概念视频
Pneumonia II: Pathophysiology
191
The pathophysiology of pneumonia involves the following steps:
191
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.7K
Pulmonary Ventilation: Inhalation
2.6K
Pulmonary ventilation is a vital process that ensures the exchange of oxygen and carbon dioxide in the lungs. It refers to the movement of air into and out of the lungs, enabling the body to obtain oxygen and remove waste carbon dioxide. In this article, we will explore the intricacies of pulmonary ventilation, including its underlying principles, mechanisms, and the interplay of pressures within the respiratory system.
Boyle's law becomes particularly pertinent when examining respiratory...
Boyle's law becomes particularly pertinent when examining respiratory...
2.6K
Common Respiratory Disorders
181
Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
181
Acute Respiratory Failure-V
113
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Ensure that patients are monitored continuously for their response to therapy, including changes in...
113
Anatomy of Respiratory System II: Lower Respiratory Tract
519
The lower respiratory tract is anatomically composed of several vital structures, including the larynx, trachea, bronchial tree, alveoli, lungs, and pleurae. Each component has a specific function, and all are intricately connected to ensure efficient respiration.
The Larynx
It is located between the pharynx and the trachea, acts as a passageway for air, and hosts several critical structures, such as the epiglottis, vocal cords, and glottis. The epiglottis acts as a gateway, guiding food to the...
The Larynx
It is located between the pharynx and the trachea, acts as a passageway for air, and hosts several critical structures, such as the epiglottis, vocal cords, and glottis. The epiglottis acts as a gateway, guiding food to the...
519
