尼沃卢马布诱导的史蒂文斯-约翰逊综合征/有毒表皮亡的临床特征:基于病例报告的回顾性分析
Ronghui Li1, Haibo Lei1, Chunjiang Wang2
1Department of Clinical Pharmacy, Xiangtan Central Hospital (The Affiliated Hospital of Hunan University), Xiangtan, Hunan, China.
Frontiers in immunology
|April 2, 2025
概括
史蒂文斯-约翰逊综合征/有毒表皮解 (SJS/TEN) 是对尼沃卢马布的严重反应. 这项研究详细介绍了SJS/TEN的临床特征,强调了长时间的潜伏期和不良预后,这对监测和治疗至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
背景情况:
- 史蒂文斯-约翰逊综合征/有毒表皮解 (SJS/TEN) 是一种罕见但危及生命的与尼沃卢马布治疗相关的免疫相关不良事件.
- 了解尼沃卢马布诱导的SJS/TEN的临床谱对于及时诊断和有效管理至关重要.
研究的目的:
- 为了研究SJS/TEN的临床特征,在患者治疗nivolumab.
- 为诊断和治疗尼沃卢马布诱导的SJS/TEN提供必要的数据.
主要方法:
- 对截至2024年12月31日发表的文章进行了系统的文献搜索,重点是尼沃卢马布诱导的SJS/TEN.
- 从相关研究中提取和分析数据,以总结关键的临床特征和结果.
主要成果:
- 包括31名患者,平均年龄为65岁. SJS/TEN发作发生在nivolumab开始后的中位数为5.5周.
- 常见的皮肤表现包括水泡/水泡 (64.5%),红血症 (54.8%),皮肤皮疹 (54.8%). 组织病理学揭示了表皮亡 (41.9%) 和炎症透 (45.2%).
- 虽然74.2%的患者在停用尼沃卢马布和治疗后出现改善,但TEN的死亡率达到22.6%.
结论:
- 尼沃卢马布诱导的SJS/TEN是一种严重的免疫相关不良事件,需要在治疗期间进行警监测.
- 这种疾病的特点是长时间的潜伏期,严重的临床表现,以及显著的死亡风险,这强调了迅速识别和干预的必要性.
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