减肥手术后肥胖患者的口腔微生物组变化与瘦身患者相比,减肥手术后的口腔微生物组变化
Keun-Suh Kim1, Hee Sam Na2, Tae Jung Oh3,4
1Department of Periodontology, Section of Dentistry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Frontiers in microbiology
|April 2, 2025
概括
与瘦个体相比,肥胖个体具有不同的口腔微生物组概况. 肥胖患者的腹腔外科手术导致口腔微生物群向更健康的状态转移,这表明减肥对口腔健康有好处.
科学领域:
- 微生物组研究的研究.
- 口腔健康 口腔健康
- 代谢性疾病是一种代谢性疾病.
背景情况:
- 肥胖与改变的微生物群落有关.
- 口腔微生物组在肥胖中的作用及其通过减肥干预措施的潜在调节需要进一步研究.
研究的目的:
- 为了比较肥胖和瘦弱个体之间的口腔微生物组概况.
- 评估腹手术后肥胖个体的口腔微生物组变化.
主要方法:
- 招募肥胖 (BMI > 30) 和瘦 (BMI < 23) 的参与者.
- 分析了唾液,口腔和下微生物组样本的多样性和丰富性.
- 利用微力来进行β-多样性的统计分析.
主要成果:
- 与对照组相比,肥胖个体表现出明显的口腔微生物组α多样性和组成.
- 在唾液,口腔和下样本中观察到微生物组合的显著差异.
- 腹腔外科手术后,肥胖患者表现出向更健康的口腔微生物群的转变,减少了牙周病原体.
结论:
- 肥胖与口腔微生物组的显著变化有关.
- 腹腔外科手术和随后的体重减轻促使人们转向更健康的口腔微生物特征.
- 减肥干预可以积极影响口腔微生物群落,即使没有临床牙周炎.
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