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一种通用的交叉播种方法来实现蛋白质结晶

Ido Caspy1, Shan Tang2, Dom Bellini1

  • 1MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, CambridgeCB2 0QH, United Kingdom.

Journal of applied crystallography
|April 2, 2025
PubMed
概括

这项研究引入了一种使用通用蛋白质晶体碎片的新型交叉播种方法,以克服X射线晶体学中的结晶挑战. 这种方法成功地产生了对视网膜母细胞瘤结合蛋白9的衍射质量晶体,从而推进了结构生物学.

关键词:
在X射线晶体学.交叉播种是一种交叉播种.大分子结晶的结晶化.核化的核化.蛋白质晶体是一种蛋白质晶体.

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