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瘤微环境的机制病理学:检测技术,分子机制和治疗机会

Stella Angeli¹, Constantina Neophytou¹, Maria Kalli¹

¹Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus.

Frontiers in cell and developmental biology

|April 2, 2025

概括

瘤微环境 (TME) 的机械特性在生长过程中发生变化,影响进展和治疗. 了解这些生物力学力量是开发有效癌症治疗的关键.

科学领域:

生物医学工程生物医学工程
癌症生物学癌症生物学
机械生物学机械生物学

背景情况:

瘤微环境 (TME) 的机械特性在瘤生长过程中发生显著变化.
改变的细胞外矩阵 (ECM) 刚性和瘤粘弹性驱动瘤进展.
这些机械变化通过影响药物输送和激活亲瘤源机械传导通路来阻碍治疗疗效.

研究的目的:

审查改变的TME中瘤细胞机械信号传感和传输的机制.
探索机械传导通路的计算建模策略.
讨论测量瘤机械性质的方法以及TME恢复和阻止放松调节的机械传导的策略.

主要方法:

在TME中对机械传导通路的文献综述.
对机械信号的计算建模方法的分析.
对测量瘤机制和治疗策略的临床方法的调查.

主要成果:

瘤细胞积极感知并传输机械信号,以保持在机械改变的TME中稳态.
目前用于机械传导的计算模型需要改进,以包括更多的机械信号组件.
存在各种方法来测量瘤的机械性质,并且正在出现恢复TME和阻断机械传导的策略.

结论:

在组织和细胞水平上全面了解TME的机械环境至关重要.
在治疗策略中考虑机械力对于提高治疗疗效至关重要.
准机械传导通路为癌症治疗提供了一个有希望的途径.

关键词:

细胞机械传导是细胞的机械传导.计算建模计算建模机械力量机械力量是指机械力量.机械病理学的机制.组织硬,组织硬.瘤微环境是一个微环境.

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