甘油三和发生糖尿病之间的关联:基于中国队列研究的二次回顾分析
Hui Peng1, Bin Wang1, Wei Yang1
1Department of General Practice, Shenzhen second People's Hospital (The First Affiliated of Shenzhen University), Shenzhen, Guangdong, 518000, People's Republic of China.
高水平的甘油三与中国成年人糖尿病风险增加有关. 随着甘油三水平低于1.27mmol/L,风险显著增加,但超过这一值,风险会下降.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 流行病学 流行病学
背景情况:
- 三甘油 (TG) 水平和糖尿病 (DM) 风险相关性受到争论.
- 在中国人群中,关于这种联系的研究有限.
研究的目的:
- 调查中国人的TG水平与DM发病率之间的相关性.
- 探索非线性关系并确定转折点.
主要方法:
- 一个回顾性队列的二次分析 (202,888名中国参与者,2010-2016).
- 使用了考克斯回归,灵敏度分析和立方斜线函数.
- 一个由两部分组成的考克斯模型确定了DM风险的TG拐点.
主要成果:
- 在DM的参与者中观察到基线TG水平升高.
- 经过调整后的分析显示,TG水平和发生的DM之间存在正相关性 (HR: 1.25).
- 患DM的风险在较高的TG三位数时显著增加,并且在1.27 mmol/L以下显著增加 (HR:2.35).
结论:
- 在中国人群中,TG水平与DM风险有积极的非线性关联.
- 在1.27mmol/L以下的TG水平上升显著增加了DM风险.
- 在1.27mmol/L以上,更高的TG水平与较低的DM风险有关.
更多相关视频
08:13Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
08:47Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
Published on: December 7, 2017
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
Diabetes: Symptoms, Diagnosis, and Complications
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Obesity
