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瘤免疫疗法针对B7-H3:从机制到临床应用

Yining Guo^1,2, Xudong Wang², Chen Zhang²

¹College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, People's Republic of China.

ImmunoTargets and therapy

|April 2, 2025

概括

B7-H3 (CD276) 是一种免疫检查点分子,通过抑制免疫反应和通过非免疫功能促进瘤进展. 准B7-H3对癌症免疫疗法有很大的希望.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
分子生物学分子生物学

背景情况:

B7-H3 (CD276) 是一个B7家族的免疫检查点分子.
它在各种瘤细胞中异常表达,充当联合抑制分子.
B7-H3在促进瘤微环境 (TME) 内的瘤进展方面发挥着至关重要的作用.

研究的目的:

在瘤中合成B7-H3的表达模式.
阐明B7-H3通过免疫调节和非免疫功能促进瘤进展的机制.
在癌症治疗中审查针对B7-H3的治疗策略.

主要方法:

文献综述和对B7-H3.3现有研究的综合.
分析B7-H3在TME内的免疫细胞功能中的作用.
检查B7-H3对瘤细胞的非免疫作用.
对针对B7-H3.3的现有和新兴免疫疗法的审查.

主要成果:

B7-H3 损害T细胞反应,并促进与瘤相关的巨细胞 (TAMs) 的M2极化.
它抑制其他免疫细胞功能,导致免疫抑制性TME.
B7-H3增强了瘤细胞的增殖,迁移,入侵,代谢失调,血管生成和治疗耐药性.
B7-H3具有免疫和非免疫功能,可以促进瘤的进展.

结论:

B7-H3是通过多种机制促进瘤进展的重要驱动因素.
针对B7-H3,单独或与其他免疫疗法结合,是一个可行的治疗策略.
进一步研究B7-H3的功能可以为各种癌症的新型临床治疗提供信息.

关键词:

B7-H3 (CD276) 这是一本书.免疫检查点是一个检查点.瘤是一个瘤.瘤免疫疗法免疫疗法瘤微环境是一个微环境.

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