丹诺苏马布治疗对经更年期骨质疏松症患者骨密度以外的疼痛和功能的影响:一项前性研究
Miao Zheng1, Xiong-Yi Wang2, Ke-Yu Zhu1
1Osteoporosis Clinical Center, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Orthopaedic surgery
|April 2, 2025
概括
在绝经后的骨质疏松症患者中,denosumab治疗显著改善了疼痛和功能,腰椎骨矿物质密度增加与缓解疼痛有很强的相关性. 以前的脆弱性骨折改善了治疗结果.
科学领域:
- 骨科和骨代谢 骨科和骨代谢
- 药理学和治疗学 药理学和治疗学
背景情况:
- 绝经后骨质疏松症 (PMOP) 导致骨质损失,导致骨折,疼痛和功能减弱.
- 有效的治疗方法旨在增加骨矿物质密度 (BMD),预防骨折,改善生活质量.
- 德诺苏马布已被FDA批准用于骨质疏松症,但其对中国PMOP患者疼痛和功能的影响需要进一步调查.
研究的目的:
- 研究德诺苏马布对中国PMOP患者疼痛和功能的影响.
- 为了确定影响德诺苏马布治疗疼痛和功能有效性的因素,在这个人群中.
主要方法:
- 一项针对200名PMOP患者进行的前性研究,这些患者接受了德诺苏马布,和维生素D治疗.
- 在基线和12个月时评估疼痛 (NRS),功能 (ODI),骨代谢标志物和骨质量.
- 分析了疼痛,功能,BMD和影响因素之间的相关性.
主要成果:
- 德诺苏马布治疗显著减少疼痛 (NRS) 和改善功能 (ODI).
- 骨代谢标志物下降,骨质量增加,特别是在腰椎.
- 疼痛和功能的改善与腰椎骨质量增加正相关.
结论:
- 在PMOP患者中,denosumab治疗在12个月后显著改善了疼痛和功能障碍.
- 与腰椎骨质量相关的疼痛改善;与部和脊椎骨质量相关的功能增强.
- 之前的脆弱性骨折和之前没有使用抗骨质疏松症药物预测了更好的结果.
相关概念视频
01:40Bone Remodeling
38.2K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.2K
01:29Bone Disorders
3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K
01:31Osteoclasts in Bone Remodeling
2.8K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.8K
01:29Blood and Nerve Supply to the Bones
10.8K
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
10.8K
01:17Hormones and Bone Tissue
2.6K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.6K
01:28Menopause
145
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
145