一位老年妇女左腿上的异常结节-一个病例报告:挑战挑战
Gerardo Cazzato1, Giuseppe Ingravallo1, Paola Vitiello2
1Section of Molecular Pathology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari "Aldo Moro", Bari, Italy ; and.
The American Journal of dermatopathology
|April 2, 2025
概括
本案例研究详细介绍了一种罕见的碰撞腺囊基细胞癌和血细胞状树突细胞瘤 (BPDCN) 在一个71岁的女人. 这些发现强调了彻底的组织病理学对于诊断不寻常的皮肤病变的重要性.
科学领域:
- 皮肤病理学 皮肤病理学
- 血液病理学 血液病理学
- 在瘤学瘤学.
背景情况:
- 基底细胞癌 (BCC) 是最常见的皮肤癌.
- 囊性血细胞状树突细胞瘤 (BPDCN) 是一种罕见且具有攻击性的血液性恶性瘤.
- 碰撞瘤,即两个不同的瘤在同一个部位出现,很少被报告.
研究的目的:
- 报告第一个已知的基细胞癌和BPDCN之间的碰撞损伤病例.
- 突出诊断挑战和在不典型的皮肤病变综合性遗传病理学评估的重要性.
主要方法:
- 对结节性,性腿部病变和类似伤的四肢病变进行组织学检查.
- 使用包括CD123,CD4,CD56和TCL1.1在内的标记物的免疫组织化学分析.
- 使用Ki67染色对扩散指数的评估.
主要成果:
- 组织病理学揭示了基底细胞癌与腺囊性特征和BPDCN.的碰撞.
- 免疫组织化学证实BPDCN具有较高的扩散指数 (Ki67>90%).
- 患者呈现出一种独特的皮肤病变组合.
结论:
- 这是第一个报告的基细胞癌和BPDCN之间的碰撞案例.
- 综合性组织病理学和免疫组织化学评估对于精确诊断罕见和侵袭性瘤至关重要.
- 这种碰撞损伤需要仔细的诊断考虑.
相关概念视频
01:13Radiological Investigation III: Pulmonary Angiogram and PET Scan
76
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
76
01:30Skin Cancer
3.0K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
3.0K
01:11Assessing Blood pressure in the Leg
1.8K
Proper measurement of leg blood pressure is a critical skill for healthcare providers, ensuring precise and reliable readings. When performed correctly, this procedure informs patient care and enhances the efficacy of interventions. The following text outlines step-by-step guidelines to measure blood pressure in the leg, providing clarity and ease of understanding for practitioners.
Preparation:
Preparation:
1.8K
01:27Assessment of the Cardiovascular System III: Palpation
162
Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
162