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一个生物打印的脉冲式喷泉导管的多物理模拟.

Zinan Hu1, Jessica E Herrmann2,3, Erica L Schwarz4,5

  • 1Department of Mechanical Engineering, Stanford University, Stanford, CA 94305.

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概括

一个新的生物打印脉动导管为单心室心脏患者提供了一个潜在的解决方案,通过降低静脉压力和增加心脏输出,显著改善Fontan循环血液动力学.

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科学领域:

  • 生物医学工程 生物医学工程
  • 心血管生理学心血管生理学
  • 再生医学是一种再生医学.

背景情况:

  • 单心室先天性心脏病需要缓解性Fontan手术.
  • 喷泉循环导致中心静脉压力升高,心脏输出量减少,结果不佳.
  • 现有的Fontan生理学带来了重大的临床挑战.

研究的目的:

  • 提出和评估一个生物打印的脉动导管作为Fontan循环的二次电源.
  • 使用多物理计算框架优化管道设计.
  • 调查管道改善Fontan生理学和减少不良后果的潜力.

主要方法:

  • 开发一个多物理计算框架,整合电生理学,心肌细胞收缩性和流体结构相互作用.
  • 将导管模型连接到一个代表Fontan生理学的一次性参数网络.
  • 模拟各种心肌收缩水平,收缩时间,纤维方向和门位置.

主要成果:

  • 最初的管道设计使肝脏 (下静脉) 的压力从16.4mmHg降低到9.3mmHg,心脏输出量增加了29%.
  • 使用门的优化设计将肝脏压力降至7.3 mmHg,心脏输出量增加38%,接近正常的血液动力学.
  • 导管对于性能至关重要;它们的缺失会损害结果.
  • 一个潜在的缺点是,上 vena cava 压力线性增加,肝压力降低.

结论:

  • 一个生物打印的脉动导管可以显著改善Fontan循环的血液动力学.
  • 计算建模对于指导这种生物医学设备的设计是有效的.
  • 需要进一步的研究来解决潜在的缺点,如上 vena cava 压力升高.