关键的真菌共感染:流行病学,致病机制,以及其他方面
Danielle L Silva1, Nalu T A Peres1,2, Daniel A Santos1,2
1Microbiology Department, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, State of Minas Gerais, Brazil.
mBio
|April 2, 2025
概括
常常被忽视的真菌共感染,与艾滋病毒,SARS-CoV-2和结核病等疾病越来越常见. 了解这些复杂的相互作用对于改善患者的治疗结果和公共卫生战略至关重要.
科学领域:
- 菌类学和传染病的研究
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 性共感染是一个日益严重的全球健康问题,由于历史上忽视了真菌病,经常被低估.
- 这些共感染发生在各种病原体上,包括人类免疫缺陷病毒 (HIV),严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2),流感,结核菌菌和伪菌物种.
- 常见的真菌共感染包括:白病,阿斯伯吉洛斯病,密码球菌病,细胞质菌病和粘菌菌病.
研究的目的:
- 审查与主要传染病相关的真菌共感染的流行率和机制.
- 详细介绍基础疾病和真菌共感染之间的具体相互作用.
- 突出风险因素,病理生理学,流行病学和真菌共感染的诊断挑战.
主要方法:
- 在艾滋病毒,SARS-CoV-2,流感,结核病和伪omonas的背景下对真菌共感染的文献综述.
- 对促进真菌共感染发展的局部和系统机制的分析.
- 检查宿主-病原体相互作用和疾病特异性的变化.
主要成果:
- 与艾滋病毒相关的免疫抑制,SARS-CoV-2引起的炎症和流感相关的细胞因子风暴增加了对真菌共感染的易感性.
- 结核病改变了肺部结构,而Pseudomonas-Aspergillus相互作用涉及营养竞争,影响了共感染的动态.
- 阐明了每个疾病-真菌共感染配对背后的特定机制.
结论:
- 真菌共同感染对公共卫生构成重大负担,需要增加认识和研究.
- 了解宿主免疫,原发性感染和真菌病原体之间的复杂相互作用对于有效的管理至关重要.
- 改善早期诊断和有针对性的干预措施是必要的,以减少与真菌共感染相关的死亡率和发病率.
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