在澳大利亚野生马种群中的Clostridioides difficile
Natasza M R Hain-Saunders1, Daniel R Knight2,3, Andrea Harvey4
1Biosecurity and One Health Research Centre, Harry Butler Institute, Murdoch University, Murdoch, Western Australia, Australia.
Applied and environmental microbiology
|April 2, 2025
概括
在11.8%的澳大利亚野马中发现了Clostridioides difficile,发现了新的菌株. 野生马可能会在社区中充当C. difficile的水库.
科学领域:
- 兽医微生物学 兽医微生物学
- 环境健康 环境健康
- 一个健康 流行病学
背景情况:
- 困难菌 (C. difficile) 是各种动物物种腹和结肠炎的重要原因.
- 虽然C. difficile在养马群中很常见,但其在野马群中的流行程度在很大程度上仍未得到研究.
- 了解非化动物中的C. difficile对于"一健康"的方法来控制其传播至关重要.
研究的目的:
- 调查澳大利亚野马中C. difficile的流行率和特征.
- 评估野马作为C. difficile传播的储库的潜在作用.
- 为比较野马与养马中的C. difficile提供基线.
主要方法:
- 在澳大利亚五个司法管辖区收集了380匹野马的便样本.
- 进行培养以分离C. difficile,随后进行PCR核型定型和毒素分析.
- 对抗菌素敏感性测试是在孤立菌株上进行的.
主要成果:
- 艰难的C.从11.8% (45/380) 的野马样本中分离出来.
- 确定了40种不同的核核型,其中70%是新型;一些与人类,牲畜或土壤菌株相匹配.
- 发现了18种毒性菌株,其中8种具有二进制毒素基因;大多数菌株对测试的抗微生物药物敏感.
结论:
- 澳大利亚的野马携带了C. difficile,虽然比养马的患病率要低.
- 在野马中发现了新的C. difficile菌株,这表明环境适应或独特的水库.
- 野生马便是社区中C. difficile的潜在来源,这凸显了环境监测的重要性.
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