头骨特性对连续波跨骨聚焦超声波传输的影响
Han Li1,2, Isla Barnard1, Tyler Halliwell1
1School of Science and Engineering, University of Dundee, Dundee, DD1 4HN, United Kingdom.
The Journal of the Acoustical Society of America
|April 2, 2025
概括
聚焦超声波神经调节面临着由于骨波相互作用的挑战. 这项研究量化了由头骨特性引起的声损失和焦点变化,揭示了能量传递的潜在不确定性.
科学领域:
- 神经外科 神经外科
- 生物医学工程 生物医学工程
- 声学 声学 声学 声学
背景情况:
- 超的聚焦超声波提供最少的侵入性脑神经调节.
- 头骨骨显著干扰超声波传输,使精确的能量传递复杂化.
- 了解这些相互作用对于有效的治疗应用至关重要.
研究的目的:
- 综合检查聚焦超声波产生的内声场.
- 评估骨特征如何影响声传输.
- 调查影响大脑中聚焦超声波能量沉积的因素.
主要方法:
- 在12个人类头骨样本 (10个历史样本,2个蒂尔包装样本) 上进行了声场测绘.
- 超声波在220,650和1000kHz进行.
- 分析了头骨特性 (厚度,密度,曲率) 和传感器参数 (角度,间距),以了解它们对声场的影响.
主要成果:
- 观察到显著的声压插入损失,根据频率和头骨类型而异 (例如,历史头骨在1000kHz时~15dB).
- 头骨厚度和曲率的变化影响了内峰值压力,功率和焦点区域.
- 传感器的角度和距离有助于波浪叠加,导致30-40%的峰值内压力不确定性.
结论:
- 头骨特征显著减弱和扭曲聚焦的超声波场.
- 头骨特性和传感器位置的变化在治疗能量传递中带来了相当大的不确定性.
- 需要进一步的研究来优化可靠的神经调节的跨的聚焦超声协议.
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