在Th9压缩后由益生菌治疗诱导的早期亲和抗炎性免疫反应:脊髓和骨之间的相互作用
Mária Ileninová1, Katarína Kiss Bimbová1, Alexandra Kisucká1
1Institute of Neurobiology of Biomedical Research Center, Slovak Academy of Sciences, Košice, Slovakia.
The European journal of neuroscience
|April 2, 2025
概括
益生菌Lacticaseibacillus paracasei Ž2通过调节脊髓和肠道中的免疫标记物来减少脊髓损伤 (SCI) 后的炎症. 这种疗法促进神经保护,并减轻两个位置的损伤影响.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 脊髓损伤 (SCI) 引发了显著的炎症反应,加剧了二次损伤.
- 目前对SCI炎症的治疗方法有限,需要新的治疗策略.
研究的目的:
- 在SCI的老鼠模型中研究益生菌菌株Lacticaseibacillus paracasei Ž2的抗炎和神经保护作用.
- 分析益生菌治疗对脊髓和骨中益生菌和抗炎性标记物的影响.
主要方法:
- 在老鼠中诱导Th9脊髓压缩.
- 每天服用Lacticaseibacillus paracasei Ž2 (5 × 10^9 CFU/mL) 的时间为7天或14天.
- 评估脊髓和阴组织中的炎症标志物 (例如CD11b,CD68,IL-6,iNOS,C1q,TLR/NF-κB通路) 和神经保护分子 (例如IL-4Rα,TGF-β,SOCS3,Ptx3,TLR9,IFN-γ) 的评估.
主要成果:
- 益生菌治疗显著降低了脊髓中在病变部位和周围区域的促炎标志物.
- 与较短的治疗相比,为期14天的益生菌治疗对阴炎的影响更为明显.
- 益生菌治疗增强了脊髓组织中的神经保护性和抗炎性标记物,包括微质和星质转录物.
- 治疗调节了免疫调节标志物,导致功能重塑和降低了出血量.
- 较长时间的益生菌治疗提高了神经保护分子的调节,并调节了肠道炎症.
结论:
- 在亚急性阶段,Lacticaseibacillus paracasei Ž2有效地管理脊髓和肠道中SCI诱导的炎症.
- 益生菌干预表明神经保护和缓解SCI相关病理的潜力.
- 该研究强调了SCI病理生理学和益生菌治疗策略中的肠-脊髓轴.
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