InVAErt网络用于一次性参数血液动力学模型的摊销推断和识别分析
Guoxiang Grayson Tong1, Carlos A Sing-Long2, Daniele E Schiavazzi1
1Department of Applied and Computational Mathematics and Statistics, University of Notre Dame College of Science, Notre Dame, IN 46556, USA.
概括
这项研究引入了inVAErt网络,从电子健康记录 (EHR) 中估计心血管模型参数. 这种数据驱动的方法克服了识别能力的挑战,即使使用不完整的数据,也可以实现准确的生理逆转.
科学领域:
- 计算生物学是一种计算生物学.
- 生物医学工程 生物医学工程
- 系统生理学 系统生理学
背景情况:
- 从电子健康记录 (EHR) 中估计心血管模型参数是具有挑战性的,因为识别问题.
- 不能识别,无论是结构性的还是实际的,都使生理学建模中的反向问题复杂化.
- 当前的方法经常使用规范化,这可能会限制发现多个有效解决方案.
研究的目的:
- 引入和评估inVAErt网络,一个用于数字双胞胎分析的新型神经网络框架.
- 在心血管模型中解决参数估计的反向问题.
- 通过使用各种数据集来证明inVAErt网络在生理逆转中的能力.
主要方法:
- 在VAErt网络中使用,数据驱动的神经网络框架.
- 将框架应用于一个六个隔间一次性参数的血液动力学模型.
- 在合成和现实世界的电子健康记录数据上测试了该方法,包括缺失组件的场景.
主要成果:
- inVAErt网络有效地处理了心血管模型参数估计中的识别性挑战.
- 该框架在生理逆转方面表现出灵活性和有效性.
- 对缺少组件的真实数据的成功应用突出了实际实用性.
结论:
- inVAErt网络提供了一种强大的数据驱动方法,用于增强动态系统的数字双胞胎分析.
- 该方法为电子健康记录的参数估计提供了强大的解决方案,克服了识别能力的局限性.
- 这一框架有望推进医疗保健和生物系统中的心血管建模和生理逆转.
相关概念视频
01:25Transformers with Off-Nominal Turns Ratios
126
In scenarios involving parallel transformers with disparate ratings, developing per-unit models requires accommodating off-nominal turns ratios. This situation arises when the selected base voltages are not proportional to the transformer’s voltage ratings. Consider a transformer where the rated voltages are related by the term a. If the chosen voltage bases satisfy a relationship involving term b, term c is defined as the ratio of these bases. This ratio is then substituted into the...
126
01:14Node Analysis for AC Circuits
262
Consider an angioplasty system featuring a catheter equipped with a turbine, a critical tool for removing plaque deposits from coronary arteries. This intricate medical device operates using a circuit model reminiscent of a dual-node RLC circuit powered by a current-controlled voltage source.
To unravel the complexities of this system, nodal analysis is employed, a powerful technique founded on Kirchhoff's current law (KCL), which remains valid for phasors. AC circuits can effectively be...
To unravel the complexities of this system, nodal analysis is employed, a powerful technique founded on Kirchhoff's current law (KCL), which remains valid for phasors. AC circuits can effectively be...
262
01:11Nodal Analysis with Voltage Sources
917
Nodal analysis is a remarkably effective method used in electrical engineering to simplify the analysis of complex circuits, including those with dependent or independent voltage sources. Its strength lies in its systematic approach to breaking down circuits into manageable components, making it easier for engineers to understand and solve.
Consider a circuit that contains four resistors and two voltage sources, as shown in Figure 1. One of these voltage sources is connected between a...
Consider a circuit that contains four resistors and two voltage sources, as shown in Figure 1. One of these voltage sources is connected between a...
917
01:20Mesh Analysis
488
Mesh analysis is a valuable method for simplifying circuit analysis using mesh currents as key circuit variables. Unlike nodal analysis, which focuses on determining unknown voltages, mesh analysis applies Kirchhoff's voltage law (KVL) to find unknown currents within a circuit. This method is particularly convenient in reducing the number of simultaneous equations that need to be solved.
A fundamental concept in mesh analysis is the definition of meshes and mesh currents. A mesh is a closed...
A fundamental concept in mesh analysis is the definition of meshes and mesh currents. A mesh is a closed...
488
01:29Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving
34
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
34
01:14Circuit Terminology
565
An electrical network is a system composed of interconnected elements, such as resistors, capacitors, inductors, and voltage or current sources. Unlike a circuit, an electrical network does not necessarily form a closed path. In other words, while all circuits can be considered networks due to their interconnected nature, not every network qualifies as a circuit.
A circuit, on the other hand, is also an interconnected system of electrical elements but must contain one or more closed paths.
A circuit, on the other hand, is also an interconnected system of electrical elements but must contain one or more closed paths.
565