对计算机模型进行系统的结构差异评估
Michael Goldstein1, Ian Vernon1, Jonathan A Cumming1
1Department of Mathematical Sciences, Durham University, Durham, UK.
概括
本研究定义并区分计算机模拟器中的内部和外部模型差异. 它介绍了一种使用模拟器实验评估结构差异的实用方法,用生物模型证明了这一点.
科学领域:
- 计算机建模和模拟.
- 生物系统中的不确定性量化.
背景情况:
- 模型或结构差异量化计算机模拟器输出和现实世界系统之间的差异.
- 差异来自于模型简化,实施选择以及未知的或未发现的科学特征.
- 区分内部和外部差异对于准确的模拟器分析至关重要.
研究的目的:
- 定义和区分内部和外部模型的差异.
- 提出一种可处理的方法来评估计算机模型中的结构差异.
- 用一个生物模型来说明拟议的方法.
主要方法:
- 通过模拟器实验来评估内部差异的定义.
- 将外部差异定义为在内部实验的范围之外.
- 使用计算机模型的实验数据开发结构差异评估的工作流程.
主要成果:
- 成功定义和区分内部和外部差异.
- 提出了评估结构差异的实用方法.
- 在一个简单的生物模型上展示了该方法的应用.
结论:
- 拟议的方法提供了一种可处理的方法来评估结构差异.
- 了解和量化差异对于生物和医疗保健中的可靠计算机模拟至关重要.
- 这项工作有助于在复杂系统中量化不确定性.
相关概念视频
Stereotype Content Model
13.9K
The Stereotype Content Model (SCM) was first proposed by Susan Fiske and her colleagues (Fiske, Cuddy, Glick & Xu, 2002; see also Fiske, 2012 and Fiske, 2017). The SCM specifies that when someone encounters a new group, they will stereotype them based on two metrics: warmth—or that group’s perceived intent, and how likely they are to provide help or inflict harm—and competence—or their ability to carry out that objective. Depending on the warmth-competence...
13.9K
Mechanistic Models: Compartment Models in Individual and Population Analysis
19
Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
19
Typical Model Studies
175
Fluid mechanics model studies often utilize scaled-down systems to predict fluid behavior in full-scale environments, such as river flows, dam spillways, and structures interacting with open surfaces. Maintaining Froude number similarity in river models is crucial, as it replicates surface flow features like wave patterns and velocities.
175
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving
34
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
34
Modeling and Similitude
138
Scaled modeling is a fundamental technique in engineering, enabling the study of large and complex systems by creating smaller, manageable replicas that recreate critical characteristics of the original. In hydrology and civil infrastructure, for example, scaled models of dams help analyze water flow, turbulence, and pressure. This method allows for accurate predictions of real-world behavior within a controlled environment, significantly reducing the cost and time involved in full-scale...
138
Structural Classification of Joints
3.1K
Joints, also known as articulations, are classified based on their structural characteristics, i.e., based on whether the articulating surfaces of the adjacent bones are directly connected by fibrous connective tissue or cartilage, or whether the articulating surfaces contact each other within a fluid-filled joint cavity. These differences serve to divide the joints of the body into three structural classifications.
A fibrous joint is where the adjacent bones are united by fibrous connective...
A fibrous joint is where the adjacent bones are united by fibrous connective...
3.1K


