肌肉内对口服安丹塞特朗用于治疗急性脱水腹和吐的儿童:随机对照试验
Shubham Satyesh1, Rajesh Kumar Meena1, Dheeraj Shah2,3
1Department of Pediatrics, University College of Medical Sciences (University of Delhi) and Associated Guru Teg Bahadur Hospital, Dilshad Garden, New Delhi, 110095, India.
肌内的丹塞特朗在治疗儿童急性腹和脱水相关的吐方面没有明显的益处,而不是口服丹塞特朗. 这两种方法在改善口服补水治疗利用率方面同样有效和安全.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 临床药理学 临床药理学
背景情况:
- 伴随吐的急性腹是一种常见的儿科疾病.
- 控制吐对于口服补水疗法 (ORT) 的成功至关重要.
- 丹塞是一种有效的抗药,但在这种情况下,需要对其施用途径进行评估.
研究的目的:
- 为了比较肌肉内注射 (IM) 丹塞特朗与口服丹塞特朗的疗效和安全性.
- 评估丹塞特朗给药途径对儿童口服补水疗法 (ORT) 使用的影响.
- 评估Ondansetron在急性腹和脱水管理期间控制吐的有效性.
主要方法:
- 一项开放的随机对照试验与3个月至12岁的儿童进行.
- 参与者呈现急性腹,一些脱水,并在6小时内至少有两次吐.
- 在开始ORT之前,儿童接受了单剂量IM或口服丹塞 (0.2 mg/kg).
主要成果:
- 在ORT失效率方面,IM和口服丹塞组之间没有发现显著差异 (31%对24.1%).
- 这两组在需要静脉注射液体,ORS摄入量,吐频率和护理人员满意度方面表现相似.
- 对于任何一种药物注射途径都没有报告任何不良事件.
结论:
- 肌肉内注射的丹塞似乎对患有急性腹,吐和部分脱水的儿童没有比口服丹塞更大的优势.
- 口服丹塞是一种可行的和有效的替代品,用于控制吐,以促进儿科患者的ORT.
- 这项研究支持在这种临床场景中使用口服丹塞作为安全有效的选择.
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