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Feedback Regulation of Calcium Concentration

Feedback Regulation of Calcium Concentration

Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...

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Updated: May 16, 2025

Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology

Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology

Published on: April 18, 2018

在细胞结构中模拟移动的波.

Patrick A Shoemaker¹, Bo M B Bekkouche^2,3

¹Computational Science Research Center, San Diego State University, San Diego, CA, USA. pshoemaker@sdsu.edu.

Journal of computational neuroscience

|April 2, 2025

概括

细胞结构中的波以再生方式传播,速度高达每秒数百微米. 瑞诺丁受体显著影响波特征,特别是在类似树突的过程中.

科学领域:

细胞动态细胞动态
计算神经科学是一种计算神经科学.
生物物理学的生物物理.

背景情况:

波对于细胞信号传输和时空处理至关重要.
了解控制波传播的参数对于破译细胞功能至关重要.

研究的目的:

为了研究细胞结构中旅行波的参数依赖性.
阐明解剖学和生理学因素如何影响波浪特征,如速度和振幅.

主要方法:

旅行波的参数模拟研究.
模拟内醇三酸盐和氨酸受体.
在树状过程和细胞体中波传播的分析.

主要成果:

波在一系列参数上是完全再生的.
蜂分叉导致不稳定的制度中的周期性峰.
波速范围从每秒几十到几百微米,受受体存在和密度的影响.

结论:

瑞诺丁受体显著增强波的速度和振幅.
受体密度和扩散是波特征的关键决定因素.
模拟揭示了细胞结构中信号传递的复杂动态.

关键词:

星球细胞是星球细胞.波是一种波.细胞过程是细胞的过程.细胞内的细胞内.这些神经元是神经元.旅行波浪的旅行.

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Calcium Imaging in Freely Behaving Caenorhabditis elegans with Well-Controlled, Nonlocalized Vibration

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Membrane Remodeling of Giant Vesicles in Response to Localized Calcium Ion Gradients

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Published on: April 18, 2018

Calcium Imaging in Freely Behaving Caenorhabditis elegans with Well-Controlled, Nonlocalized Vibration

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Membrane Remodeling of Giant Vesicles in Response to Localized Calcium Ion Gradients

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