基于万科米辛的标记物指导在骨合成装置和手术脱bridement上的细菌的现场可视化
Gerbren B Spoelstra1, Philip H Elsinga1, Jan Maarten van Dijl2
1Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713 GZ, The Netherlands.
概括
使用万科米辛标记物的新成像技术可以检测骨植入物上的细菌感染. 这种联合的正电子发射断层扫描 (PET) 和光成像指导了手术切除受感染的生物膜.
科学领域:
- 生物医学成像学 生物医学成像学
- 传染病诊断 传染病诊断 传染病诊断
- 肌肉骨感染管理的管理
背景情况:
- 骨合成植入物上的细菌感染难以诊断,经常被误认为是无菌炎症.
- 准确的检测对于有效的手术治疗和患者的治疗结果至关重要.
研究的目的:
- 为了评估对细菌向的正子发射断层扫描 (PET) 追踪器和近红外光追踪器的联合使用.
- 检测受感染的骨质合成植入物并指导手术干预.
主要方法:
- 带有细菌生物膜的骨质合成板被用PET的[18F]PQ-VE1-菌素和光学成像的vancomycin-IRDye800CW进行成像.
- PET/CT和光成像在人骨样本的手术除菌前后量化细菌负载.
主要成果:
- 在脱bridement之前,PET成像显示受感染的板块上的标记物吸收量 (2.2倍) 与未受感染的板块相比显著更高.
- 脱bridement后,PET信号是最小的,证实有效的生物膜去除.
- 光引导的手术允许实时可视化和去除生物膜.
结论:
- 联合手术前PET和手术内光成像为非侵入性感染检测提供了一种新的方法.
- 这种双模式成像策略在骨合成植入物感染的情况下,有助于实时感染管理.
关键词:
细菌生物膜是一种细菌生物膜.细菌成像剂是一种细菌成像剂.清算 清算 清算 清算 清算光指导手术是指导手术.与骨折相关的感染.人类的死后检查.接近红外的光效应.定子发射断层扫描 (PET) 是一种定子发射断层扫描.范科米辛是一种药物.更多相关视频
07:48High Spatial Resolution Chemical Imaging of Implant-Associated Infections with X-ray Excited Luminescence Chemical Imaging Through Tissue
Published on: September 30, 2022
1.2K
06:18A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
Published on: March 3, 2023
1.3K
相关概念视频
01:24iChip
107
The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...
107
01:24Automated Microbial Diagnostics
79
Automated diagnostic analyzers have transformed clinical microbiology by providing rapid and reliable methods for pathogen identification and antibiotic susceptibility testing. Among these systems, the Vitek 2 is widely used because it automates the traditionally labor-intensive processes of microbial identification (ID) and antibiotic susceptibility testing (AST), delivering standardized and timely results that are essential for effective patient care.Microbial Identification with ID CardsThe...
79