进化和影响Imine降解酶 (IREDs) 研究:一个知识映射方法
Qilong Yao1, Yujun Hu1, Ziwei Liu1
1State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210023, China.
Molecular biotechnology
|April 2, 2025
概括
胺氨酸还原酶 (IREDs) 是合成药品中氨酸的重要酶. 这项图书统计研究绘制了IRED研究的地图,揭示了关键研究人员和酶工程和应用中的新兴趋势不断增长的领域.
科学领域:
- 生物催化和酶工程 生物催化和酶工程
- 药用化学 医学化学
- 合成生物学 合成生物学
背景情况:
- 胺胺是活性药物成分的必不可少的组成部分.
- 胺基还原酶 (IREDs) 催化了用于性胺基合成的关键反应.
- 需要对IRED研究演变进行全面的概述.
研究的目的:
- 进行对Imine Reductase (IRED) 研究的文献计量和知识映射分析.
- 探索研究格局,并确定该领域的趋势和合作.
- 为未来IRED应用的研究方向提供见解.
主要方法:
- 从2010年到2024年,对239篇文章和评论进行了图书统计分析 (Web of Science核心集合).
- 使用CiteSpace,VOSviewer,Pajek和Scimago Graphica进行知识映射.
- 分析出版趋势,引用数量,协作网络和关键词.
主要成果:
- IRED出版物和引用的持续增长,自2014年以来加速增长.
- 英国在出版物方面处于领先地位;尼古拉斯·J·特纳是被广泛引用的关键研究人员.
- 主要研究领域包括IRED结构,蛋白质工程和工业应用,如级联反应.
结论:
- 图书统计分析提供了IRED研究趋势和合作的视觉表现.
- 合成生物学和酶工程的进步将推动对非对称合成的IRED进一步开发.
- 这项研究有助于研究人员确定IRED研究的关键领域和潜在合作者.
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