尿铜与脂质不良症有关,这种关联是由炎症介导的
Sisi Xie1, Zoltan Kutalik2,3,4, Aurélien Thomas5,6
1Department of Medicine, Internal Medicine, Lausanne University Hospital (CHUV) and University of Lausanne, Rue du Bugnon 46, 1011, Lausanne, Switzerland.
尿中的铜水平与血液脂质的改变有关,特别是甘油三和高密度胆固醇. 通过hs-CRP测量的炎症部分调解了这些影响,突出了它在铜中的作用.
科学领域:
- 环境健康 环境健康
- 生物化学 生物化学
- 公共卫生 公共卫生
背景情况:
- 脱脂症是一个重大的公共卫生挑战.
- 铜在脂质代谢中的作用被怀疑但尚未完全理解,可能与炎症有关.
- 由高灵敏性C反应蛋白 (hs-CRP) 表示的炎症可能会调解铜对脂质的影响.
研究的目的:
- 研究尿铜度与主要血脂标记物之间的关联:总胆固醇 (TC),LDL-C,HDL-C和甘油三 (TG).
- 评估炎症 (hs-CRP) 在尿铜和脂质特征之间的关系中的潜在调解作用.
主要方法:
- 采用来自Collaus PaddyPsyCoLaus队列 (n=6284) 的基线数据进行横截面研究.
- 用ICP-MS测量尿铜;通过标准化生化分析评估脂质概况和hs-CRP.
- 统计分析包括多重线性回归和使用SGmediation2.2的调解分析.
主要成果:
- 尿中的铜与TG呈正相关性,与HDL-C呈负相关性.
- 尿中的铜与hs-CRP有积极的关联.
- hs-CRP部分调解了尿铜与TG (31.4%调解) 和HDL-C (56.9%调解) 之间的关联.
结论:
- 尿中的铜度与失脂症标志物有关,特别是TG和HDL-C.
- hs-CRP在这些协会中发挥了部分调解作用,特别是在TG监管方面.
- 这些发现强调了环境因素 (铜),炎症和脂质代谢之间的相互作用.
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