儿童早期的臭氧暴露以及儿童喘和喘息
Logan C Dearborn1, Marnie F Hazlehurst2, Allison R Sherris1
1Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle.
JAMA network open
|April 2, 2025
概括
早期暴露于臭氧 (O3) 与儿童喘和喘息有关,在6岁时,但在9岁时没有. 减少O3污染可能会减少儿童喘的负担.
科学领域:
- 环境健康科学 环境健康科学
- 儿科呼吸系统医学 儿科呼吸系统医学
- 流行病学 流行病学
背景情况:
- 臭氧 (O3) 是一种常见的空气污染物,短期暴露与呼吸系统问题有关.
- 关于产后O3暴露和儿童喘/喘息的证据不一致,特别是在考虑污染物混合物时.
研究的目的:
- 调查环境O3暴露与儿童喘/喘息之间的关联.
- 为了评估O3与细颗粒物和二氧化一起.
- 检查通常年度O3度较低的地区的结果.
主要方法:
- 一项综合的多站点队列研究 (ECHO-PATHWAYS联盟,2007-2023) 包括来自美国6个城市的1188名儿童.
- 从出生到2岁的住宅地址历史被用来通过时空模型估计O3暴露.
- 使用后勤回归和贝叶斯内核机器回归 (BKMR),对共变量进行调整.
主要成果:
- 较高的O3暴露 (每2ppb) 与4-6岁的当前喘 (OR 1.31) 和喘息 (OR 1.30) 的几率增加有关.
- 对于8-9岁的结果,没有发现有意义的关联.
- BKMR表明O3混合物暴露与幼儿喘和喘息有关.
结论:
- 早期生活中的环境O3暴露与幼儿时期 (4-6岁) 的喘和喘息有关.
- 这些关联甚至在O3度较低的地区和考虑污染物混合物时也被观察到.
- 减少O3暴露可能会减轻儿童喘对公众健康的影响.
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