创伤性脑损伤与精神障碍或自杀之间的关联中的遗传混
Søren Dinesen Østergaard1,2, Jessica Mundy1,2, Alisha Silvia Mercedes Hall1,2
1Department of Affective Disorders, Aarhus University Hospital - Psychiatry, Aarhus, Denmark.
JAMA psychiatry
|April 2, 2025
概括
对精神疾病的遗传倾向可能解释了创伤性脑损伤 (TBI) 与精神健康状况之间的一些观察到的联系. 未来的研究应该考虑遗传责任,以避免高估TBI.
科学领域:
- 精神病学和遗传学 精神病学和遗传学
- 神经科学和流行病学
背景情况:
- 创伤性脑损伤 (TBI) 很普遍,与精神障碍和自杀有关.
- 观察性研究表明存在关联,但由于遗传责任等潜在的混因素,因果关系尚不清楚.
研究的目的:
- 调查精神疾病的遗传责任是否混了TBI和心理健康结果之间的观察到的关联.
- 评估多基因风险评分 (PRSs) 在预测TBI风险方面的作用.
主要方法:
- 一项队列研究利用了伦德贝克基金会综合精神病学研究倡议 (iPSYCH) 样本的丹麦人口.
- 基因型个体的PRS计算为精神分裂症,双相情感障碍,抑郁症和ADHD.
- 考克斯的比例危险回归分析了PRS和TBI发病率之间的关联,并通过医院诊断进行了操作.
主要成果:
- 这项研究包括40,274人,其中3,341人患有TBI.
- 四种PRS (精神分裂症,双相情感障碍,抑郁症,多动症) 都显示出与TBI的统计学上显著的积极关联.
- 对精神分裂症 (HRR 1.06),双相情感障碍 (HRR 1.04),抑郁症 (HRR 1.10) 和多动症 (ADHD) (HRR 1.12) 的增加PRS与较高的TBI风险有关.
结论:
- 精神疾病的遗传责任可能会混TBI与心理健康结果或自杀之间的关联.
- 研究结果表明,遗传因素有助于观察到的联系,可能导致对TBI的直接因果作用的高估.
- 未来的研究应该包括遗传责任评估,以准确评估TBI对心理健康的影响.
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