相关实验视频

Updated: May 8, 2025

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management

Published on: February 28, 2025

香衍生的外体样纳米带有抗氧化物质的水凝加载加快伤口愈合

Ting Wang¹, Yilong Li¹, Linlin Hao¹

¹College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong, 266404, China.

Macromolecular bioscience

|April 2, 2025

概括

在水凝中的衍生纳米纤维 (CDEN) 通过减少炎症和增强抗氧化防御来促进伤口愈合. 这种新的CDENs-水凝通过多个阶段加速愈合,为伤口管理提供了一个有希望的替代方案.

科学领域:

生物材料科学生物材料科学
再生医学是一种再生医学.
纳米技术纳米技术

背景情况:

氧化应激和炎症显著影响伤口愈合过程.
来自植物的外体样纳米纤维显示出潜在的抗氧化和抗炎作用.
这些纳米纤维在伤口愈合中的精确机制需要进一步阐明.

研究的目的:

为了隔离和表征衍生的外体类纳米纤维 (CDENs).
评估基于CDENs的水凝在体内伤口愈合的疗效.
调查 CDENs 的治疗效果背后的分子机制.

主要方法:

从西红中分离和表征CDEN.
在体外评估CDEN对HaCaT细胞和ROS清理的影响.
开发一个装有CDENs的水凝,用于持续释放.
在小鼠体内进行伤口愈合研究,分析巨细胞两极分化,血管生成和原沉积.
对Nrf2信号通路激活的研究.

主要成果:

细胞和组织成功地分离和内化了CDEN.
CDENs促进了HaCaT细胞迁移,清理了活性氧物种 (ROS),并减少了炎症.
在不同的伤口愈合阶段,CDENs-hydrogel促进了M2巨细胞两极分化,血管生成和原沉积.
CDENs-水凝激活了Nrf2信号通路,增强了抗氧化防御和减少了炎症.

结论:

CDENs-水凝显示出加速伤口愈合的巨大潜力.
Nrf2通路的激活是CDEN治疗效果的一个关键机制.
CDENs-水凝代表了一种有前途,安全和有效的临床伤口管理替代方案.

关键词:

香 - - 菜 - - 菜 - - 菜 - - 菜类似于外体的纳米纤维.这是一种水凝.氧化应激是一种氧化应激.伤口愈合伤口愈合

更多相关视频

Ex Vivo Corneal Organ Culture Model for Wound Healing Studies

Ex Vivo Corneal Organ Culture Model for Wound Healing Studies

Published on: February 15, 2019

Formulation of Zinc-Based Nanomaterials using the Eucommia ulmoides Bark Extract and their Wound Healing Potential

Formulation of Zinc-Based Nanomaterials using the Eucommia ulmoides Bark Extract and their Wound Healing Potential

Published on: December 27, 2024

相关概念视频

Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...

Phases of Wound Repair

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...