长期暴露于乙醇会导致在条形体中价值计算的性别依赖性损害
Yifeng Cheng1,2, Robin Magnard1, Angela J Langdon3
1Department Psychological and Brain Sciences, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD, USA.
Science advances
|April 2, 2025
概括
长期暴露于乙醇会损害适应性决策,并改变状神经活动,特别是在男性中. 这些对神经计算和行为的长期影响显示出明显的性别差异.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 神经生物学 神经生物学 神经生物学
背景情况:
- 基于价值的决策取决于条纹体,这是一个神经可塑性可能会受到慢性乙醇 (EtOH) 暴露影响的大脑区域.
- 在决策过程中EtOH诱导的神经可塑性对条状神经动态的确切影响仍然不完全理解.
研究的目的:
- 调查慢性乙醇暴露对奖励驱动的决策和条状神经计算的长期影响.
- 检查慢性乙醇暴露和随后戒断的行为和神经反应的性别特异性差异.
主要方法:
- 在雄性和雌性大鼠中利用动态概率逆转学习任务.
- 评估行为适应性,探索性行动和以结果为导向的价值更新.
- 分析了与结果和选择编码相关的背中条体 (DMS) 中的神经活动.
主要成果:
- 暴露在乙醇中的雄性大鼠表现出降低了适应能力,受损的探索行为和异常的价值更新,有利于先前选择的行动.
- 这些男性的行为缺陷与结果相关的神经编码的增加以及在DMS中选择相关编码的减少有关.
- 雌性大鼠表现出较少的行为障碍,但在神经活动中表现出明显的EtOH引起的改变,突出显著的性别差异.
结论:
- 长期暴露于乙醇会导致适应性决策的持续缺陷,并改变条形体内的神经计算过程.
- 在乙醇戒断后,条状神经动态的持久变化有助于认知障碍,具有显著的性别特异性变化.
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