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用68Ga-FAPI-46 PET/CT揭露的桃腺状细胞癌

Jiaqing Liu^1,2, Xiyi Liao^1,2, Yizhen Pang^1,2

¹Department of Radiation Oncology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University.

Clinical nuclear medicine

|April 2, 2025

概括

使用68Ga-FAPI-46的正子发射断层扫描/计算机断层扫描 (PET/CT) 有效地定位了患有未知原发性转移性状细胞癌的患者的原发性瘤,其表现优于18F-FDG PET/CT.

科学领域:

核医学就是核医学.
在瘤学瘤学.
放射化学放射化学是指辐射化学.

背景情况:

未知初级 (CUP) 的状细胞癌 (SCC) presents一个诊断挑战.
氧葡萄糖 (FDG) PET/CT是一种标准的成像方法,但在检测某些初级瘤时可能受到限制.
纤维细胞激活蛋白 (FAP) 越来越多地被认为是各种癌症成像的目标.

研究的目的:

评估68Ga-FAPI-46 PET/CT在识别未知原发性转移性SCC患者中原发性瘤部位的有用性.
在这个特定的临床场景中,将68Ga-FAPI-46 PET/CT与18F-FDG PET/CT的发现进行比较.

主要方法:

一名55岁的女性患者患有左转移性SCC,接受了18F-FDG PET/CT和68Ga-FAPI-46 PET/CT.
对这两种成像方式的放射追踪器吸收模式进行了分析.
根据PET/CT发现进行了临床检查和活检.

主要成果:

18F-FDG PET/CT没有检测到原发性恶性瘤.
68Ga-FAPI-46 PET/CT 显示左 palatine 桃体的辐射标记物吸收增加,表明主要瘤部位.
左桃体的组织学检查证实了状细胞癌.

结论:

68Ga-FAPI-46 PET/CT在未知原发性转移性SCC病例中发现原发性恶性瘤的显著附加值.
这一案例凸显了针对FAPI的PET/CT作为CUP的优越成像工具的潜力,与标准的FDG PET/CT相比.

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