库辛综合征的死亡率:在20多年内下降,但仍然高于一般人群
Amit Akirov1,2, Maria Fleseriu3, Hiba Masri-Iraqi1,2
1Institute of Endocrinology, Beilinson Hospital, Rabin Medical Center, Petah Tikva 49100, Israel.
European journal of endocrinology
|April 2, 2025
概括
患有库辛综合征 (CS) 的患者面临更高的死亡率,特别是患有活跃疾病的患者. 达到缓解显著改善了生存率,强调了疾病控制对CS患者的重要性.
科学领域:
- 内分泌学 在内分泌学.
- 内部医学 内部医学
- 公共卫生 公共卫生
背景情况:
- 内源性库辛综合征 (CS) 与死亡率增加有关,特别是在活跃的疾病阶段.
- 以前的分析表明,上腺癌和库辛病 (CD) 的死亡率在2000年后降低了,但往往缺乏匹配的对照.
研究的目的:
- 评估与匹配的对照组相比,内源性CS患者的全因死亡率.
- 研究高皮质醇症缓解,疾病源和其他风险因素对CS患者死亡率的影响.
主要方法:
- 在以色列 (2000-2023) 进行了一项全国性的回顾性队列研究,利用了Clalit健康服务数据库.
- 609名内源性CS患者与基于年龄,性别,社会经济地位和BMI的对照进行了1:5的匹配.
- 主要结局是全因死亡率;次要结局包括因特定死亡率和缓解影响.
主要成果:
- 在平均16年的随访期间,CS患者的死亡风险比对照患者高出44% (HR=1.44).
- 库辛病 (HR=1.73) 和上腺癌 (HR=1.31) 均显示死亡率增加.
- 2年内没有缓解与较高的死亡率有关 (HR=1.44),而疾病病因对死亡率没有显著影响.
结论:
- 这一庞大的全国队列证实了与匹配的对照组相比,内源性CS患者的死亡风险明显更高.
- 疾病缓解是影响CS患者长期生存的关键因素.
- 有效的疾病管理和控制对于改善结果和降低库辛综合征死亡率至关重要.
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