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储蓄障碍患者与注意力缺陷/多动障碍并发症的患者的自发活动和功能连接
Hirofumi Tomiyama1, Keitaro Murayama2, Kenta Kato1
1Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Japan.
Journal of psychiatric research
|April 2, 2025
概括
储蓄障碍 (HD) 患者在右下额 (IFG) 中显示出大脑活动的改变. 与注意力缺陷/多动障碍 (ADHD) 的并发症进一步降低了IFG和背侧前额皮层 (DLPFC) 之间的功能连接.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
背景情况:
- 储蓄障碍 (HD) 越来越多地与注意力缺陷/多动障碍 (ADHD) 相关.
- 以前的神经成像研究没有区分患有或没有ADHD并发症的HD患者.
- 了解这些差异对于开发有针对性的治疗策略至关重要.
研究的目的:
- 研究HD患者的区域自发活动和功能连接性.
- 专门研究患有ADHD (HD+ADHD) 和没有ADHD (HD-ADHD) 的HD患者之间的差异.
- 探索HD的神经生物学基础及其与ADHD的并发症.
主要方法:
- 休息状态功能磁共振成像 (fMRI) 数据从24名HD患者和31名健康对照 (HCs) 中获得.
- 低频波动的分数振幅 (fALFF) 用于评估区域自发活动.
- 使用改变的fALFF区域作为种子进行了功能连接性分析,比较HCs,HD+ADHD和HD-ADHD组.
主要成果:
- 与HC患者相比,HD患者在右下额 (IFG) 中的fALFF减少.
- 功能连接性分析显示,与HC相比,HD+ADHD组的IFG与背侧前额皮层 (DLPFC) 之间的连接性显著降低.
- 在HD-ADHD组显示HD+ADHD和HCs组之间的中间连接水平.
结论:
- 患有HD的患者在IFG中表现出改变的自发活动.
- 在HD患者中,ADHD的并发症与IFG和DLPFC之间的功能连接显著减少有关.
- 研究结果强调需要区分HD子组 (有或没有ADHD) 进行精细的神经生物学模型和未来的治疗干预.
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