在COVID-19后新发性强迫症和青少年肠炎相关的关节炎 (三个病例)
Developmental neuroscience
|April 2, 2025
概括
后COVID-19感染可以引发强迫症 (OCD) 和炎症. 关节成像可能会显示系统性免疫激活,指导神经精神病症状的早期免疫调节治疗.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
背景情况:
- 强迫症 (OCD) 与炎症有关.
- COVID-19感染与神经精神症状有关,包括强迫症.
- 在COVID-19后也报告了症状性关节炎.
研究的目的:
- 描述COVID-19后临床恶化呈现给免疫行为健康诊所的情况.
- 为了调查COVID-19与神经精神病衰退和全身炎症之间的联系.
主要方法:
- 对151名患者的回顾性图表审查.
- 确定了三个确诊的COVID-19病例,这些病例在神经精神病学恶化之前出现.
- 对所有患者进行综合性风湿病和关节炎评估,包括超声波成像.
主要成果:
- 这三名患者在COVID-19后都出现了新发作或重新升级的强迫症.
- 在成像上,所有三名患者都表现出关节炎症 (排泄物+/- 突炎+/- 囊炎),尽管关节疼痛最小.
- 两名患者符合儿科急性发病神经精神综合征 (PANS) 的标准.
结论:
- 感染可以触发系统性免疫激活和炎症,表现为神经精神疾病症状.
- 关节炎症可以作为神经精神病例中系统性免疫激活的可访问指标.
- 早期免疫调节治疗 (NSAIDs +/- DMARDs) 改善了神经精神病和关节炎的发现.
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