在被非活化COVID-19疫苗接种后患有膜性病患者的复发风险
Hanzhen Zhang1, Ruiying Chen2, Mingyue Xu2
1Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China, 15301050144@fudan.edu.cn.
Nephron
|April 2, 2025
概括
失活的COVID-19疫苗接种并没有增加患有膜性病的患者复发或恶化的风险. 这项研究在接种疫苗和未接种疫苗的人群中发现了类似的结果,这表明疫苗对这个患者群体的安全性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 报告表明,在COVID-19疫苗接种后,膜性病可能复发或恶化.
- COVID-19疫苗和膜性病恶化之间的因果关系仍然未确立.
研究的目的:
- 为了调查在不活化COVID-19疫苗接种后膜性病复发或恶化的发生.
- 评估非活化COVID-19疫苗接种对膜性病结局的影响.
主要方法:
- 353名膜性病患者 (186名接种疫苗,167名未接种疫苗) 的回顾性研究.
- 在蛋白尿 <3.5g/d的患者中,在12个月内监测复发/恶化.
- 使用枢机性匹配来平衡接种疫苗和未接种疫苗组之间的基线变量.
主要成果:
- 在匹配后,接种疫苗 (13%) 和未接种疫苗 (15%) 组之间的复发或恶化率没有显著差异.
- 在接种疫苗和未接种疫苗的患者中,复发/恶化的危险比为0.98 (95% CI 0.42-2.33).
- 未接种疫苗的患者表示担心由于免疫抑制疗法而导致疾病复发和疫苗疗效.
结论:
- 失活的COVID-19疫苗似乎不会增加患有膜性病的患者复发或恶化的风险.
- 研究结果表明,非活化COVID-19疫苗对于患有膜性病的人来说可能是安全的.
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