干细胞分化和瘤进化的单细胞植物动力学推断
Kun Wang1, Zhaolian Lu2, Zeqi Yao3
1School of Mathematical Sciences, Xiamen University, Xiamen 361005, China; National Institute for Data Science in Health and Medicine, Xiamen University, Xiamen 361102, China.
Cell systems
|April 2, 2025
概括
scPhyloX模型细胞种群使用家族遗传树来研究组织发育和瘤进化动态. 这种计算框架推断了动态生物过程的时间变化的参数.
科学领域:
- 计算生物学 计算生物学
- 进化生物学 进化生物学
- 基因组学就是基因组学.
背景情况:
- 遗传学推断 (PI) 通过遗传学树来分析种群动态.
- 单细胞谱系追踪使细胞水平PI成为可能,但由于细胞分化和进化,在体组织中面临挑战.
- 现有的PI框架并不直接适用于复杂的体质组织动态.
研究的目的:
- 介绍scPhyloX,一个用于建模结构细胞群的计算框架.
- 使用单细胞遗传树推断组织发育和瘤进化动态.
- 为了使动态生物过程的时间变化的参数可以推断.
主要方法:
- 利用单细胞遗传树来建模结构化的细胞群.
- 开发一个计算框架 (scPhyloX) 来推断组织发育和瘤进化.
- 实施方法来推断动态生物过程的时间变化的参数.
主要成果:
- scPhyloX准确地推断了组织发育,疾病治疗和瘤生长的模拟场景中的动态.
- 对真实数据集的分析揭示了对器官发育 (干细胞过剩) 的见解.
- 鉴定了人类衰老中的克隆扩张和结直肠癌中的亚克隆选择.
结论:
- scPhyloX为研究体组织发育和进化提供了一种新的计算方法.
- 该框架增强了对多细胞生物体中动态生物过程的理解.
- 应用范围从发育生物学到癌症研究,为研究提供了新的途径.
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