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Updated: May 16, 2025

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
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在使用生理学基础生物制药模型预测结肠光线和组织度的梅萨拉胺和乙梅萨拉胺的挑战

Harshad Jadhav1, Arno Van Camp2, Christer Tannergren3

  • 1Digital Science, x-Sustainable Innovation & Transformational Excellence, Pharmaceutical Technology & Development, AstraZeneca Gothenburg, 43183 Mölndal, Sweden; Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Gasthuisberg O&N II, Herestraat 49 - Box 921, 3000 Leuven, Belgium.

International journal of pharmaceutics
|April 2, 2025
PubMed
概括

基于生理学的生物制药模型 (PBBM) 准确地预测了梅沙胺 (5-ASA) 血水平,但与结肠组织度作斗争. 需要进一步的研究来完善胃肠道药物分发的模型.

关键词:
吸收方式 吸收方式生物制药产品的建模.结肠的光线度是大肠的光线度.梅萨拉胺是一种美沙胺.在NAT1中使用NAT1.美国的 PBBM PBBM组织中的度度.

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