缺点:喘中的临床缓解 - - 还没有出现
Lauren Eggert1, Sarah Rhoads2, Michael E Wechsler3
1Division of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA, USA.
概括
由于症状的变化,肺功能变化和并发症,定义喘缓解是具有挑战性的. 目前的定义需要改进,以便在喘管理中实现实际,可测量和有意义的临床应用.
科学领域:
- 肺部病理学 肺部病理学
- 临床医学 临床医学
- 喘研究 喘研究
背景情况:
- 定义喘缓解对于评估真正的疾病改变至关重要.
- 目前的定义缺乏实用性,可测量性和对患者和医生的临床意义.
- 喘固有的复杂性对建立共识定义构成重大挑战.
研究的目的:
- 讨论发展广泛采用的喘缓解的共识定义的障碍和挑战.
- 突出创造一个实用,可衡量和有意义的定义的困难.
- 在喘缓解的背景下探索"超级响应者"的概念.
主要方法:
- 使用关键词进行文献搜索:"喘"",缓解"和"超级响应者".
- 在喘中识别和分析干预试验.
- 基于现有研究和临床观察,讨论挑战.
主要成果:
- 目前关于喘缓解定义的建议是不充分的.
- 症状感知,肺功能,季节性和并发症的变化使定义发展复杂化.
- 干预试验揭示了定义喘缓解的固有挑战.
结论:
- 开发一种普遍接受的喘缓解定义仍然是一个重大挑战.
- 克服与喘异质性相关的障碍对于实用和有意义的定义至关重要.
- 需要进一步的研究来完善喘缓解和疾病修饰的标准.
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