[配方设计有助于开发适合儿童的药物]
1Department of Pharmaceutics, Showa University Graduate School of Pharmacy.
概括
在2-6岁的儿童中,儿童迷你片 (MTs) 的吞能力低于细粒 (FGs) 和液体配方 (LFs). 然而,婴儿 (6-11个月) 显示出更好的MT吞能力,表明药物配方特定的年龄考虑药物坚持.
科学领域:
- 儿科药理学 儿科药理学
- 制药技术 制药技术 制药技术
- 药物输送系统是药物输送系统.
背景情况:
- 在儿童中,最佳的药物坚持需要适合年龄的配方.
- 迷你平板电脑 (MTs) 是一种新的儿科配方,在欧洲和美国越来越受欢迎.
- 细颗粒 (FG) 和液体配方 (LF) 是日本和其他地方常见的儿科剂型.
研究的目的:
- 在儿童中评估无毒小片 (MTs) 与细颗粒 (FGs) 和液体配方 (LFs) 相比的可接受性.
- 评估年龄对不同儿科口服配方的吞性和口味性的影响.
- 为了确定配方可接受性对儿科药物坚持性的影响.
主要方法:
- 一项涉及无药物迷你片 (MTs),细颗粒 (FGs) 和液体配方 (LFs) 的比较研究.
- 参与者包括6个月至8岁的儿童,他们访问了儿科.
- 接受性主要通过医疗保健专业人员观察吞性 (不) 和家长报告的口感度来衡量.
主要成果:
- 在2-6岁的儿童中,迷你片 (MTs) 的吞能力低于FG和LF,通常是由于.
- 6至11个月的婴儿在使用MT时表现出明显更好的吞能力,而不是使用FG或LF.
- 在12-23个月的儿童中,MT,FG和LF之间没有发现可吞性的显著差异.
结论:
- 迷你平板电脑 (MT) 的可接受性因年龄而异,在学龄前儿童中存在挑战,但在婴儿中具有优势.
- 可吞性和可口性是影响儿科口服配方整体可接受性的关键因素.
- 综合的可接受性分析,包括可吞性和可口性,为开发有效的儿科药物输送系统提供了宝贵的见解.
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