在局部先进的细胞癌的生存中存在种族差异
Jean-Pierre Trey Kanumuambidi1, Dmitry Tumin2, Michael Blute1
1Department of Urology, East Carolina University, Brody School of Medicine, Greenville, NC.
Clinical genitourinary cancer
|April 2, 2025
概括
患有细胞癌 (RCC) 和瘤血栓的非裔美国人面临22%更高的死亡风险. 这种差异在转移性RCC (mRCC) 中甚至更大,突出了种族对生存结果的影响.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 健康差异 在健康上的差异
背景情况:
- 患有细胞癌 (RCC) 的非裔美国人经常经历更具侵略性的瘤和较差的结果.
- 种族对局部晚期RCC和瘤血栓或转移性RCC (mRCC) 患者的生存率的具体影响尚不清楚.
- 这项研究调查了呈瘤血栓的RCC患者生存率的种族差异.
研究的目的:
- 评估诊断为细胞癌 (RCC) 和瘤血栓的患者的生存结果的种族差异.
- 为了比较非裔美国人和非西班牙裔白人患者与RCC和瘤血栓之间的死亡风险.
- 为了确定影响这种患者群体生存的潜在人口因素.
主要方法:
- 来自国家癌症数据库 (2010-2015) 的11520名RCC患者 (18-80岁) 瘤血栓的回顾性分析.
- 包括人口 (年龄,性别,种族/民族) 和临床变量 (瘤阶段,等级,血栓水平,手术类型,并发症).
- 使用卡普兰-梅尔曲线,考克斯比例危险模型和多项逻辑回归 (P < .05显著性) 的统计分析.
主要成果:
- 与非西班牙裔白人 (83%) 相比,非洲裔美国人 (6%的队列) 的整体死亡风险高出22% (HR:1.22,P <.001).
- 在患有转移性RCC (mRCC) 的非裔美国人中观察到24%的死亡风险增加 (HR:1.24,P = .019).
- 晚期血栓水平 (I-IV) 的五年生存率在不同种族群体中相似;整体死亡率为55% (转移病例为82%).
结论:
- 与非西班牙裔白人患者相比,患有RCC和瘤血栓的非裔美国患者的死亡风险 (22%) 显着更高.
- 非洲裔美国人更有可能出现本地晚期疾病和mRCC,导致较差的结果.
- 这些发现强调了种族对RCC存活率的重大影响,并主张在治疗非裔美国患者时进行临床考虑.
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