持续的母体低血压与异常的子宫多普勒体的关联
Stephanie Pearson1, Baillie Bronner2, Annie Dude3
1Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Rush University Medical Center, Chicago, IL, USA.
概括
怀孕期间持续的低血压并没有显著增加异常子宫动脉多普勒病的风险. 这一发现表明,在这些情况下,胎盘低输液可能与低血压没有直接联系.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 怀孕期间的心血管生理学
背景情况:
- 持续性低血压是一种在怀孕期间血压低的特征.
- 通过子宫动脉 (UtA) 多普勒评估的异常胎盘输液是怀孕期间潜在的担忧.
- 持续的低血压和异常的胎盘血流之间的联系需要进一步调查.
研究的目的:
- 评估持续低血压和异常子宫动脉 (UtA) 多普勒发现之间的关联.
- 为了确定持续的低血压是否是异常胎盘输液的危险因素.
主要方法:
- 无卵性妊娠结果研究队列的二次分析.
- 包括单独怀孕的持续低血压和完整的UtA多普勒数据.
- 在所有研究访问中,持续性低血压的定义是SBP <100 mmHg和/或DBP <60 mmHg.
- 主要结局:怀孕18-24周之间异常的UtA多普勒 (PI>95百分位或透静度分位)
- 进行了单变量和多变量分析 (根据年龄,保险,BMI,慢性高血压进行调整).
主要成果:
- 在5218名患者中,有140名 (2.7%) 患有持续性低血压.
- 患有低血压的患者更有可能拥有公共保险,较低的妊娠前BMI和吸烟.
- 未经调整的分析显示,低血压组中异常UtA多普勒的可能性更高 (45.0%对35.3%,p=0.017).
- 这种关联在多变量分析中没有持续 (aOR 1.39,95% CI 0.98-1.95).
结论:
- 怀孕期间持续的低血压与异常子宫动脉多普勒检测结果的风险增加无关.
- 该研究没有发现证据表明持续的低血压与UTA多普勒测量的异常胎盘低输液有关.
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