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Updated: May 7, 2026

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使用植物UDP-glucuronosyltransferase在酵母中表达的黄类葡萄胺的区域特异合成

Mst Julia Sultana1, Takuto Kurakawa1, Miyu Nishikawa1

  • 1Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University.

Bioscience, biotechnology, and biochemistry
|April 2, 2025
PubMed
概括

这项研究介绍了一种可持续的酵母生物转化方法,用于生产黄类葡萄化物. 这种方法有效地产生了特定的氨酸葡萄化物,提高了它们在药物开发中的可用性.

关键词:
生物转化 生物转化黄类葡萄糖化物 黄类葡萄糖化物 黄类葡萄糖化物葡萄糖的化植物葡萄糖基转移酶的作用尿素二酸盐-葡萄糖-6-脱基酶.

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Phase II Reactions: Glucuronidation01:24

Phase II Reactions: Glucuronidation

Glucuronidation, a pivotal phase II biotransformation process, involves the coupling of glucuronic acid to a drug or xenobiotic. Given its widespread occurrence and critical role in drug metabolism, it's considered the most crucial phase II reaction. It enhances the water solubility of substances, aiding their expulsion from the body. The driving force behind these reactions is a group of enzymes known as UDP-glucuronosyltransferases (UGTs). UGTs facilitate the transfer of a glucuronic acid...
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