在暴力,精神病和精神病症中,个体水平偏离了规范性大脑形态的偏差
Unn K Haukvik1,2, Thomas Wolfers3,4,5, Natalia Tesli6,5
1Adult Psychiatry Department, Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway. unn.haukvik@medisin.uio.no.
这项研究使用了规范建模来绘制精神病和/或暴力史的个体的大脑差异. 大脑的偏差是异质的,并且特定于诊断组,突出显示了个体的神经生物学变异.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 法医神经科学 法医神经科学
背景情况:
- 大脑形态异常与暴力和精神病有关,但个体差异和研究不一致性仍然存在.
- 大脑MRI特征的规范建模可以为复杂的表型绘制个体大脑特征,即使在小样本中也是如此.
- 这种方法尚未应用于法医精神病学群体.
研究的目的:
- 通过使用规范建模,探索严重暴力史和/或精神分裂症谱系障碍 (SSD) 患者的大脑异质性.
- 在法医群体中调查个体大脑偏差,群体差异以及与精神病特征的关联.
- 应用规范建模来理解伴随性暴力和精神病的神经生物学基础.
主要方法:
- 利用基于来自58,836个人的自由冲浪者兴趣区域的规范模型.
- 分析了皮层厚度,表面积和皮层下体积.
- 他们比较了四组:具有暴力的SSD (SSD-V),没有暴力的SSD (SSD-NV),没有暴力的SSD (非SSD-V) 和健康的对照 (HC).
主要成果:
- 在所有组中确定了个体大脑偏离常态的异质模式.
- 观察到SSD-V (附带横向,语言,小脑),SSD-NV (平行,次轨道) 和非SSD-V (准中心,中间前部区域) 的明显偏差模式.
- 没有发现大脑偏差和精神病特征之间的显著关联.
结论:
- 规范模型揭示了与暴力和精神病相关的异质大脑形态学偏差.
- 个体大脑偏差模式在精神病和暴力群体之间有所不同.
- 对个体大脑偏差的进一步研究可能会改善法医精神病学的理解和临床影响.
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