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Updated: May 17, 2025

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使用抗tau单域抗体抑制tau神经元内化

Clément Danis1,2,3, Elian Dupré4,5, Thomas Bouillet6

  • 1CNRS EMR9002 - BSI - Integrative Structural Biology, Lille, France. clement.danis@inserm.fr.

Nature communications
|April 2, 2025
PubMed
概括

研究人员确定了新型抗陶蛋白抗体 (VHHs),这些抗体阻断神经元吸收陶蛋白. 这些VHHs准LRP1,一个关键受体,为阿尔茨海默病治疗提供了潜在的潜力.

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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