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在使用2005年至2018年的NHANES数据的基础上,血的动脉质指数与系统性免疫-炎症指数之间的关联

Jiayu Li^1,2, Dan Hou³, Jiarong Li⁴

¹Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China.

Scientific reports

|April 2, 2025

概括

血动脉生成指数 (AIP) 和全身免疫炎症指数 (SII) 显示出显著的正相关性,特别是在女性和50岁以下的人群中. 这种关系是非线性的,类似于反转的U形,为心血管疾病风险提供了洞察力.

科学领域:

心血管健康心血管健康
炎症生物标志物炎症生物标志物
公共卫生研究公共卫生研究

背景情况:

血动脉质指数 (AIP) 评估动脉样硬化风险,而全身免疫炎症指数 (SII) 量化炎症.
AIP和SII都是预测各种疾病的公认指标.
了解AIP和SII之间的相互作用对于疾病风险评估至关重要.

研究的目的:

调查血的动脉动原指数 (AIP) 和全身免疫炎症指数 (SII) 之间的关系.

主要方法:

一项横截面研究利用了来自国家健康和营养检查调查 (NHANES) (2005-2018) 的8163名参与者 (20岁以上) 的数据.
使用了权重多重线性回归,趋势测试,平滑曲线拟合和值效应分析.
分析对共变量进行了调整,对性别和年龄进行了子组分析.

主要成果:

在完全调整的模型中,在AIP和SII之间观察到显著的正相关性 (β = 32.497,P = 0.021).
这种关系呈现出非线性"反转的U形",其拐点为AIP = 0.82.
仅在女性和50岁以下的参与者中发现了积极的关联,在不同的子组中观察到明显的非线性模式.

结论:

在AIP和SII之间存在显著的正相关性,特别明显在女性和年轻人中.
非线性"反转U形"关系表明脂质代谢和全身炎症之间的复杂相互作用.
这些发现为心血管疾病的预防和管理提供了新的视角,需要进一步的队列研究来验证.

关键词:

线性关系是一种线性关系.尼汉斯 (NHANES) 是一个名人.积极的相关性是正相关性的.血的动脉生成指数血的动脉生成指数系统性免疫-炎症指数是系统性免疫-炎症指数

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