相关实验视频
Updated: May 16, 2025

10:36
Probiotic Studies in Neonatal Mice Using Gavage
Published on: January 27, 2019
18.3K
双菌支持婴儿的最佳免疫反应
Feargal J Ryan1,2, Michelle Clarke3,4,5, Miriam A Lynn1,2
1Precision Medicine, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.
Nature
|April 2, 2025
概括
通过改变肠道微生物群,新生儿接触抗生素会影响婴儿的疫苗反应. 在小鼠中恢复Bifidobacterium物种改善了疫苗免疫力,这表明针对微生物群的干预可能是有益的.
科学领域:
- 免疫学
- 微生物学
- 新生儿健康
背景情况:
- 早期的抗生素暴露与疫苗有效性的降低有关.
- 这种免疫反应受损的潜在机制尚不清楚.
研究的目的:
- 研究早期抗生素暴露对婴儿免疫反应的影响.
- 探索肠道微生物群对这些影响的作用.
主要方法:
- 从出生到15个月的191名婴儿的预期随访.
- 系统疫苗学方法,包括抗体定位和转录分析.
- 用于分析肠道微生物组成的体基因组学.
主要成果:
- 新生儿抗生素暴露,但不是产后暴露,与肺炎球菌和Hib/ diphtheria抗原的抗体标位降低在7个月.
- 接种新生儿抗生素的婴儿在接种疫苗之前表现出炎症转录特征,并减少了Bifidobacterium的数量.
- 六个月后减少的Bifidobacterium数量与较低的疫苗抗体度相关.
- 临床前模型显示微生物群依赖于疫苗的反应,可在Bifidobacterium物种中恢复.
结论:
- 早期的抗生素暴露会通过微生物群的改变对疫苗的免疫性产生负面影响.
- 针对微生物群,例如用Bifidobacterium物种,可以恢复疫苗的反应.
- 针对微生物群的干预措施有望缓解抗生素引起的疫苗反应损伤.
相关概念视频
Development of Immunocompetence
271
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
271
Vaccinations
43.1K
Overview
43.1K
Defense Mechanism Against Infection
5.7K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
5.7K
Anatomy of the Intestines
70.8K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
70.8K
Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Active versus Passive Immunity
479
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
Active Immunity
Active immunity refers to the resistance one develops...
479

