编目复制品数变异区域以及跨越泛印度的山羊品种的相关多样性
Nidhi Sukhija1,2, K K Kanaka1,2, Indrajit Ganguly3
1ICAR-National Bureau of Animal Genetic Resources, Karnal, Haryana, 132001, India.
概括
印度山羊品种表现出显著的遗传多样性. 这项研究绘制了11种品种的副本数变异区域 (CNVR),揭示了独特的遗传特征和适应特征,这对未来的遗传研究至关重要.
科学领域:
- 基因组学就是基因组学.
- 动物遗传学动物遗传学
- 生物信息学是一种生物信息学.
背景情况:
- 羊品种具有巨大的遗传多样性,受到自然和人工选择的影响.
- 下一代测序 (NGS) 能够进行全面的全基因组变异分析.
- 了解遗传变异是提高山羊生产,适应性和抗病能力的关键.
研究的目的:
- 通过使用全基因组再测序,对11种印度山羊品种的复制数变异/区域 (CNV/CNVRs) 进行表征.
- 分析遗传多样性,人口结构,并确定与适应相关的选择特征.
- 为土著山羊种群提供CNVR的基础数据集.
主要方法:
- 11个印度山羊品种的全基因组再测序.
- 识别和分析副本数变异区域 (CNVRs).
- 种群遗传学分析,包括主要成分分析 (PCA),添加剂分析和f3统计.
- 使用VST方法检测选择签名.
主要成果:
- 划定了第一个基于重新测序的印第安山羊品种的CNV/CNVR分布,大大增加了现有的山羊CNVR数据.
- 主要组件分析 (PCA) 显示了Kanniadu (KAN) 和Jharkhand Black (JB) 品种的不同聚类.
- 混合物分析表明JB,KAN和Tellicherry (TEL) 品种具有独特的遗传结构.
- 确定与热适应相关的32个选择特征和关键基因 (例如,ZBTB7C,BHLHE22,AGT).
- 发现了32,711个自体CNVRs.
结论:
- 该研究为印度山羊品种提供了全面的CNV/CNVR景观,突出显著的遗传多样性和独特的种群结构.
- 识别的选择特征和基因为适应的遗传基础提供了洞察力,特别是热耐受性.
- 生成的数据和定制脚本是未来研究基于副本数变异的山羊遗传学和育种的宝贵资源.
相关概念视频
Comparing Copy Number Variations and SNPs
16.8K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
16.8K
Single Nucleotide Polymorphisms-SNPs
13.7K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
13.7K
Evolutionary Relationships through Genome Comparisons
5.6K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.6K
Incomplete Dominance
20.5K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
20.5K
What is Population Genetics?
57.1K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
57.1K
Genetic Drift
39.0K
Natural selection—probably the most well-known evolutionary mechanism—increases the prevalence of traits that enhance survival and reproduction. However, evolution does not merely propagate favorable traits, nor does it always benefit populations.
39.0K


