在孕前症后长期的微血管和血压失调
Maya Jälmby1, Camilla Edvinsson1, Despoina Lykou1
1Division of Obstetrics and Gynecology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
概括
孕前 (PE) 与由于内皮糖 (EG) 损伤的长期心血管风险有关. 产后6年,患有PE史的女性显示EG厚度降低和血压升高,表明持续的血管功能障碍.
科学领域:
- 心血管研究研究心血管研究
- 产科和妇科 产科和妇科
- 血管生物学 血管生物学
背景情况:
- 孕前 (PE) 是一种导致内皮损伤和未来心血管疾病的妊娠疾病.
- 内皮葡萄糖 (EG) 对于血管平衡至关重要,在PE中受到影响.
- 长期PE的血管后果需要进一步调查.
研究的目的:
- 为了评估内皮葡萄糖 (EG) 厚度和血压 (BP) 趋势,女性有先兆子 (PE) 史与正常压力怀孕.
- 评估EG完整性,血压和怀孕/新生儿结果之间的关联.
主要方法:
- 研究了一组55名女性 (18人为对照组,34人患有PE,3人患有妊娠高血压).
- 在产后6年使用侧流暗场显微镜评估了语言下微循环和EG厚度 (通过 perfused边界区域 - PBR).
- 测量了坐姿和静止血压 (BP) 以及BP变化.
主要成果:
- 与对照组相比,患有PE史的女性在血管≥8微米中显著减少了EG厚度 (增加了PBR) (3.14对2.88微米,p=0.002).
- 在PE组中观察到较高的缩/透气血压和内访血压变化.
- 孕产妇的PBR值与新生儿不良结果,动脉多普勒和妊娠和随访期间的BP有关.
结论:
- 孕前史与持续的内皮糖 (EG) 损伤和产后6年升高的血压 (BP) 相关.
- 怀孕期间血液动力学和新生儿问题的严重程度可能导致不可逆转的EG损伤和长期的母体血管功能障碍.
- 研究结果强调了EG和BP调节在产前后心血管风险增加中的作用.
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