功能丰富的表观遗传时钟揭示了癌症患者组织特异的不一致的衰老模式
Chiara M S Herzog1,2, Elisa Redl1,2, James Barrett1,2
1European Translational Oncology Prevention and Screening Institute, Universität Innsbruck, Innsbruck, Austria.
Communications medicine
|April 2, 2025
概括
表观遗传钟显示乳腺癌组织的衰老加速,但患者的一些非癌症组织的衰老减缓. 这表明不协调的系统组织衰老,影响癌症的发展和预防策略.
科学领域:
- 老年学是一门学科.
- 癌症生物学 癌症生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 老龄化是许多疾病的主要危险因素,包括癌症.
- 表观遗传变化,特别是DNA甲基化 (DNAme) 变化,是衰老的标志,是表观遗传钟的基础.
- 疾病期间不同器官中与年龄相关的DNA变化的功能相关性尚未完全理解.
研究的目的:
- 将细胞特异性与年龄相关的DNA变化与衰老特征和癌症发展联系起来.
- 调查DNA变化与癌症,致癌物暴露和死亡率的关联.
- 将发现与现有的表观遗传钟进行比较.
主要方法:
- 对细胞特异性与年龄相关的DNA甲基化 (DNAme) 变化的分析.
- 整合DNAme数据与衰老和癌症的标志 (衰老,干细胞命运基因,增殖).
- 利用来自人类 (12,510) 和小鼠 (105) 样本的大型数据集.
主要成果:
- 确定了功能丰富的DNA变化和癌症之间的关联.
- 定点DNAme网站在致癌过程中最早发生变化,以及那些将癌症与重编程区分开来的地方.
- 观察到乳腺癌组织的表观遗传衰老加速,但在乳腺癌患者的一些非癌症组织 (如宫) 中衰老减缓.
结论:
- 提供了关于与年龄相关的DNA变化在癌症中的功能作用的见解.
- 在重编程过程中确定了预防瘤形成的潜在目标.
- 在乳腺癌患者中表现出不一致的全身组织衰老.
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