在心脏代谢特征的生命过程演变中的原始父母效应
Rucha Wagh1,2, Gad Hatem3, Jonas Andersson3
1Diabetes Unit, Kamalnayan Bajaj Diabetology Research Centre, King Edward Memorial Hospital and Research Centre, Pune, India.
Diabetologia
|April 2, 2025
概括
父母的起源影响影响从出生到成年期的心脏代谢特征,在后代代谢中主要观察到母亲的影响. 这些发现突出了跨发育阶段的父母动态偏见.
科学领域:
- 遗传学和表观遗传学
- 人类发展 人类发展
- 代谢健康 代谢健康
背景情况:
- 心脏代谢特征表现出遗传性和原始基因效应,主要研究在成年人身上.
- 父母的起源效应意味着从父母之一的优先继承.
研究的目的:
- 调查出生队列中对心脏代谢特征的遗传性和原始父母的影响.
- 通过连续测量,确定这些模式是否在生命早期出现.
主要方法:
- 使用了浦那孕产妇营养研究 (分娩队列,24年随访).
- 采用截面和纵向分析 (线性回归和混合效应回归).
- 评估了使用一般化估计方程的遗传原生源效应.
主要成果:
- 对女儿的出生体重和一些肥胖特征观察到的母性原始父母效应.
- 在儿子的腰与部比 (WHR) 中观察到父亲偏差;在皮厚度方面,随着时间的推移观察到偏差的变化.
- 孕产妇偏差在禁食葡萄糖和脂质中普遍存在;在胰岛素和HOMA指数中观察到动态效应.
结论:
- 已证实源代对从出生到成年期心脏代谢特征的影响.
- 主要由母亲对子宫内,青春期和生殖年龄代谢的影响.
- 跨越生理阶段的动态父母影响可能会为原始预防策略提供信息.
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