总抗氧化能力与表型衰老加速之间的L形联系:来自NHANES 2003-2010年的证据
Yukun Wu1, Mengxiang Xiang1, Yangcheng Zhao1
1The Affiliated Changsha Central Hospital, Department of Peripheral Vascular Intervention, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.
Biogerontology
|April 2, 2025
概括
较高的总抗氧化能力 (TAC) 与较慢的生物衰老有关 (PhenoAgeAccel). 这项研究发现了TAC的保护作用,特别是在男性,吸烟者和酒精消费者身上,这表明TAC在缓解衰老方面的作用.
科学领域:
- 生物化学和分子生物学
- 老年学和衰老研究研究.
- 营养科学 营养科学
背景情况:
- 生物衰老是一个复杂的过程,可以加速,导致疾病风险增加.
- 总抗氧化能力 (TAC) 反映了身体中和有害自由基的能力.
- 现型衰老加速 (PhenoAgeAccel) 作为加速生物衰老的生物标志物.
研究的目的:
- 调查总抗氧化能力 (TAC) 和表型衰老加速 (PhenoAgeAccel) 之间的关联.
- 探索特定抗氧化维生素和PhenoAgeAccel之间的关系.
- 检查TAC-PhenoAgeAccel协会中的潜在非线性关系和效果修饰器.
主要方法:
- 分析了来自2003-2010年国家健康和营养检查调查 (NHANES) 的16395名参与者.
- 多变量后勤回归模型根据人口,生活方式和临床因素进行调整.
- 使用平滑曲线拟合和值效应分析进行非线性关系探索.
主要成果:
- 较高的TAC与PhenoAgeAccel有显著的反向关联.
- 在TAC的第二个三分之一的参与者显示,PhenoAgeAccel的几率降低了11%.
- 摄入数种抗氧化维生素 (例如,维生素C,E,β-胡卜素) 也与PhenoAgeAccel相反相关.
- 在特定范围内观察到TAC的非线性保护作用,特别是在男性,吸烟者和酒精消费者中.
结论:
- 总抗氧化能力 (TAC) 与表型衰老加速 (PhenoAgeAccel) 有显著关联.
- 存在非线性关系,较高的TAC在一定的范围内提供对加速衰老的保护作用.
- 调查结果强调了TAC在缓解衰老过程中的潜在作用,在某些人口和生活方式子组中观察到特定的好处.
更多相关视频
09:37A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
Published on: July 14, 2016
8.2K
14:39Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
Published on: April 22, 2022
3.8K
相关概念视频
01:26Aging
32
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
32
01:10Nature and Nurture
20.3K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
20.3K
02:27Background and Environment Affect Phenotype
6.4K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.4K
02:20Longitudinal Research
11.8K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
11.8K
01:37Mitochondria
9.0K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
9.0K