牛乳杆菌约翰逊菌YH1136减轻了小鼠的精神分裂症行为:一个肠道微生物群-大脑轴假设研究研究
Liqin Zheng1,2, Jinge Xin3, Huiqian Ye4
1School of Life Science and Technology, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, China.
BMC microbiology
|April 2, 2025
概括
像L. johnsonii YH1136这样的益生菌在通过调节肠道微生物群和大脑通路来治疗小鼠的精神分裂症行为方面表现有前途. 这项研究强调了心理健康障碍的潜在治疗益处.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 精神病学是一个精神病学.
背景情况:
- 微生物群-肠-大脑轴 (MGBA) 与精神疾病有关.
- 精神分裂症 (SCZ) 提出了复杂的治疗挑战.
- 益生菌正在通过MGBA调节成为SCZ的潜在治疗剂.
研究的目的:
- 在小鼠模型中研究L. johnsonii YH1136在预防SCZ类行为方面的有效性.
- 在SCZ中确定与L. johnsoniiYH1136治疗相关的关键微生物和代谢变化.
主要方法:
- 使用MK-801.1诱导了一个SCZ小鼠模型.
- L. johnsonii YH1136是通过口服进行的.
- 进行了行为测试,酶表达分析,海马BDNF水平和16SrRNA测序.
主要成果:
- L. johnsonii YH1136显著改善了SCZ类行为,包括精神运动过活和社交性.
- 治疗调节了托芬代谢酶 (TDO2, IDO1, KAT1) 和增加了海马BDNF.
- 肠道微生物群的组成发生了变化,乳酸菌增加,杜博西拉减少.
- 鉴定出N-乙神经胺酸和素是关键的介导性血清代谢物.
结论:
- L. johnsonii YH1136在小鼠中显示出SCZ类行为的治疗潜力.
- 益生菌影响肠道微生物群,托代谢和BDNF水平.
- 这些发现支持开发基于L. johnsonii的益生菌用于SCZ治疗.
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